ArticleJournal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy2021
Prolonged viral clearance of severe acute respiratory syndrome coronavirus 2 in the older aged population.
Article in Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 9 citations in OpenAlex.
- Afebrile Presentation in COPD Patients with Influenza A: A Risk Factor for Prolonged Viral Shedding.International journal of chronic obstructive pulmonary disease · 2026Article
- Prevalence of and Factors Associated With Post-Coronavirus Disease 2019 (COVID-19) Condition in the 12 Months After the Diagnosis of COVID-19 in Adults Followed in General Practices in Germany.Open forum infectious diseases · 2022Article
- SARS-CoV-2 T Cell Response in Severe and Fatal COVID-19 in Primary Antibody Deficiency Patients Without Specific Humoral Immunity.Frontiers in immunology · 2022Article
- Over 1-year duration and age difference of SARS-CoV-2 antibodies in convalescent COVID-19 patients.Journal of medical virology · 2021Article
- Prolonged SARS-Cov-2 shedding with rapid IgG antibody decay in a COVID-19 patient: A case report.Journal of clinical laboratory analysis · 2021Article
- Factors affecting duration of SARS-Cov-2 viral shedding in mildly symptomatic patients isolated in a community facility.PloS one · 2021Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA by quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR) is the standard method for the diagnosis of coronavirus disease 2019 (COVID-19). This PCR test can be positive even in patients who have recovered from the disease, and the duration for achieving viral clearance has not been clarified yet.
methodsThis study was conducted between April 3, 2020, and June 17, 2020, at the Toyama University Hospital and the Toyama Rehabilitation Home. We collected the data of patients with COVID-19, analyzing the duration until twice-consecutive negative qRT-PCR test.
resultsA total of 42 patients were enrolled. The median duration of the twice-consecutive negative qRT-PCR test was 29.0 d (interquartile range: 25.75-35.25). The longest duration of viral shedding was 73 d. The duration of viral clearance was significantly longer in the older (>65 years) group than in the younger group (34.5 d vs. 25.0 d, P < 0.0001).
conclusionThis study demonstrated that viral clearance tends to be sustained in the older adults.
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Registered trials
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