ArticleThe Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation2021
Prediction of donor related lung injury in clinical lung transplantation using a validated ex vivo lung perfusion inflammation score.
Article in The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Association of Inflammatory Profile DuringTransplant international : official journal of the European Society for Organ Transplantation · 2025Pooled it
- Research advances in consistency and variability inJournal of thoracic disease · 2026Review
- Ex Vivo Perfusion Unmasks a Proteomic Signature of Primary Graft Dysfunction in Donor Hearts.JACC. Heart failure · 2026Article
- MetaboSense: An Integrated Quantum Dot-Mediated Aptamer Assay and Modular Microfluidic Platform for Continuous In-Line Monitoring of Lung Metabolism During Ex Vivo Perfusion.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Biomarkers of standard criteria and marginal donor lungs during ex vivo lung perfusion: A comparative study.JHLT open · 2026Article
- Time as a Therapeutic Ally: The Promise of Long-Term Solid Organ and Tissue Perfusion.Transplant international : official journal of the European Society for Organ Transplantation · 2026Review
- Engineering Neutrophil Vesicles for Synergistic Protection against Ischemia/Reperfusion Injury after Lung Transplant.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- North American expert consensus on the clinical role of ex vivo lung perfusion (EVLP) with acellular perfusate.Journal of thoracic disease · 2025Review
- Infective Complications of Endobronchial Ultrasound-Transbronchial Needle Aspiration (EBUS-TBNA) and Clinical Biomarkers: A Concise Review.Diagnostics (Basel, Switzerland) · 2025Review
- Review
- Improving prognostic accuracy in lung transplantation using unique features of isolated human lung radiographs.NPJ digital medicine · 2024Article
- Evaluating the Effects of Kidney Preservation at 10 °C with Hemopure and Sodium Thiosulfate in a Rat Model of Syngeneic Orthotopic Kidney Transplantation.International journal of molecular sciences · 2024Article
- Ex vivo lung perfusion moderates gene expression differences between cardiac death and brain death donor lungs.JHLT open · 2024Article
- Prolonged dialysis duringFrontiers in immunology · 2024Article
- Mitigating the risk of inflammatory type primary graft dysfunction by applying an integrated approach to assess, modify and match risk factors in lung transplantation.Frontiers in transplantation · 2024Article
- European Society of Organ Transplantation (ESOT) Consensus Statement on Machine Perfusion in Cardiothoracic Transplant.Transplant international : official journal of the European Society for Organ Transplantation · 2024Review
- A machine-learning approach to human ex vivo lung perfusion predicts transplantation outcomes and promotes organ utilization.Nature communications · 2023Article
- Subphenotypes of frailty in lung transplant candidates.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2023Article
- Cell type- and time-dependent biological responses inFrontiers in immunology · 2023Article
- Cytokines Removal DuringTransplant international : official journal of the European Society for Organ Transplantation · 2023Article
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundEx vivo lung perfusion (EVLP) is an isolated organ assessment technique that has revolutionized the field of lung transplantation and enabled a safe increase in the number of organs transplanted. The objective of this study was to develop a protein-based assay that would provide a precision medicine approach to lung injury assessment during EVLP.
methodsPerfusate samples collected from clinical EVLP cases performed from 2009 to 2019 were separated into development (n = 281) and validation (n = 57) sets to derive and validate an inflammation score based on IL-6 and IL-8 protein levels in perfusate. The ability of an inflammation score to predict lungs suitable for transplantation and likely to produce excellent recipient outcomes (time on ventilator ≤ 3 days) was assessed. Inflammation scores were compared to conventional clinical EVLP assessment parameters and associated with outcomes, including primary graft dysfunction and patient care in the ICU.
resultsAn inflammation score accurately predicted the decision to transplant (AUROC 68% [95% CI 62-74]) at the end of EVLP and those transplants associated with short ventilator times (AUROC 73% [95% CI 66-80]). The score identified lungs more likely to develop primary graft dysfunction at 72-hours post-transplant (OR 4.0, p = 0.03). A model comprised of the inflammation score and ∆PO
conclusionsThe adoption of an inflammation score will improve accuracy of EVLP decision-making and increase confidence of surgical teams to determine lungs that are suitable for transplantation, thereby improving organ utilization rates and patient outcomes.
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