Evidence map›Paper›PMID 33781589›Full record

ArticleUltramicroscopy2021

Exploring valence states of abnormal mineral deposits in biological tissues using correlative microscopy and spectroscopy techniques: A case study on ferritin and iron deposits from Alzheimer's disease patients.

Yitian Zeng, Philip S DiGiacomo, Steven J Madsen, Michael M Zeineh, Robert Sinclair

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ultramicroscopy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Advance in Neurotoxicity Research from Development to Aging.International journal of molecular sciences · 2023
    Article
  5. Iron Deposition in Brain: Does Aging Matter?International journal of molecular sciences · 2022
    Review
  6. Review
  7. Iron and Alzheimer's Disease: From Pathology to Imaging.Frontiers in human neuroscience · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Yitian ZengDepartment of Materials Science and Engineering, Stanford University, 496 Lomita Mall, Stanford, CA 94305, USA. Electronic address: ytzeng1@stanford.edu.
Philip S DiGiacomoDepartment of Bioengineering, Stanford University, 443 Via Ortega, Stanford, CA 94305, USA.
Steven J MadsenDepartment of Materials Science and Engineering, Stanford University, 496 Lomita Mall, Stanford, CA 94305, USA.
Michael M ZeinehDepartment of Radiology, Stanford University, 1201 Welch Road, Stanford, CA 94305, USA.
Robert SinclairDepartment of Materials Science and Engineering, Stanford University, 496 Lomita Mall, Stanford, CA 94305, USA. Electronic address: bobsinc@stanford.edu.
Stanford University · US

Funding

Stanford Alzheimer's Disease Research CenterAdmin Supp: Developing iPSC models for AD and PDP30AG066515 · NIA · STANFORD UNIVERSITY · PI ELIZABETH MORMINO · 2020 to 2026
$29.0M
Nano Characterization and Nano Fabrication CoreU54CA199075 · NCI · STANFORD UNIVERSITY · PI GAMBHIR, SANJIV S · 2015 to 2019
$9.6M
Iron as an Imaging Biomarker for Inflammation in ADR01AG061120 · NIA · STANFORD UNIVERSITY · PI ZEINEH, MICHAEL M · 2019 to 2023
$3.5M
NCI NIH HHS U54 CA199075NIA NIH HHS P30 AG066515NIA NIH HHS R01 AG061120
6 · The paper itself

Abstract

Abnormal accumulation of inorganic trace elements in a human brain, such as iron, zinc and aluminum, oftentimes manifested as deposits and accompanied by a chemical valence change, is pathologically relevant to various neurodegenerative diseases. In particular, Fe

Indexed as

Alzheimer DiseaseFerritinsHumansIronMicroscopy, Electron, TransmissionMineralsSpectrometry, X-Ray EmissionFerritinsIronMineralsAlzheimer’s diseaseElectron energy loss spectroscopyFocused-ion beamMagnetic resonance imagingOxidationValenceX-ray dispersive spectroscopy

Identifiers

PMID33781589
PMCPMC8616586
OpenAlexW3137784971

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.