Evidence map›Paper›PMID 33781493›Full record

ReviewRheumatic diseases clinics of North America2021

Sexual Dimorphism in the Expression of Pain Phenotype in Preclinical Models of Rheumatoid Arthritis.

Lauriane Delay, Gilson Gonçalves Dos Santos, Elayne Vieira Dias, Tony L Yaksh, Maripat Corr

Open access · greenAbstract readReview
In one paragraph

Review in Rheumatic diseases clinics of North America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
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  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Lauriane DelayDepartment of Anesthesiology, University of California San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA. Electronic address: ldelay@health.ucsd.edu.
Gilson Gonçalves Dos SantosDepartment of Anesthesiology, University of California San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA.
Elayne Vieira DiasDepartment of Anesthesiology, University of California San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA.
Tony L YakshDepartment of Anesthesiology, University of California San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA.
Maripat CorrDivision of Rheumatology, Allergy and Immunology, University of California San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA.
University of California, San Diego · US

Funding

VIRAL MALIGNANCYP30CA023100 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jesse Nodora · 1985 to 2026
$124.9M
THERAPEUTIC PROFILES OF OPIOID DELTA RECEPTORS--NEW MODALITIESP01DA006284 · NIDA · UNIVERSITY OF ARIZONA · PI HRUBY, VICTOR J · 1989 to 2015
$14.8M
Proteolysis of Myelin as a Source of Neuropathic PainR01DE022757 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SHUBAYEV, VERONICA · 2012 to 2022
$7.3M
Characterization of Toxicity with Spinal OpiatesR01DA015353 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI YAKSH, TONY L. · 2003 to 2017
$4.4M
The Pharmacology of Spinal AnalgesicsR01DA002110 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI YAKSH, TONY L. · 1985 to 2014
$3.8M
AIBP and regulation of neuropathic painR01NS102432 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MILLER, YURY, YAKSH, TONY L. · 2017 to 2021
$3.0M
Sex, Stress and Immunity in the Acute to Chronic Pain TransitionR01NS099338 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI YAKSH, TONY L. · 2017 to 2021
$1.8M
Spinal Galanin and its Receptors in Pain ProcessingR01NS041954 · NINDS · UNIVERSITY OF CALIFORNIA SAN DIEGO · PI YAKSH, TONY L · 2002 to 2005
$1.5M
PAIN EVOKED RELEASE OF AMINO ACIDS AND PROSTANOIDSR01NS016541 · NINDS · UNIVERSITY OF CALIFORNIA SAN DIEGO · PI YAKSH, TONY L · 1985 to 2005
$1.3M
NCI NIH HHS P30 CA023100NIDA NIH HHS P01 DA006284NIDA NIH HHS R01 DA002110NIDA NIH HHS R01 DA015353NIDCR NIH HHS R01 DE022757NINDS NIH HHS R01 NS016541NINDS NIH HHS R01 NS041954NINDS NIH HHS R01 NS099338NINDS NIH HHS R01 NS102432
6 · The paper itself

Abstract

Rheumatoid arthritis is one of most frequent rheumatic diseases, affecting around 1% of the population worldwide. Pain impacting the quality of life for the patient with rheumatoid arthritis, is often the primary factor leading them to seek medical care. Although sex-related differences in humans and animal models of rheumatoid arthritis are described, the correlation between pain and sex in rheumatoid arthritis has only recently been directly examined. Here we review the literature and explore the mechanisms underlying the expression of the pain phenotype in females and males in preclinical models of rheumatoid arthritis.

Indexed as

Arthritis, RheumatoidSex CharacteristicsAnimalsFemaleHumansMalePainPhenotypeQuality of LifePainRheumatoid arthritisSexual dimorphism

Identifiers

PMID33781493
PMCPMC8015200
OpenAlexW3133963791

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.