Trial reportBMC pulmonary medicine2021
Early rehabilitation relieves diaphragm dysfunction induced by prolonged mechanical ventilation: a randomised control study.
Trial report in BMC pulmonary medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05953649 (Effect of Early Extracorporeal Diaphragm Pacing （EDP） Combined With Tilt Table Verticalization （TTV) on Diaphragm Function in Critically Ill Patients With Mechanical Ventilation), which is not on this map. Cited by 35 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Early Extracorporeal Diaphragm Pacing （EDP） Combined With Tilt Table Verticalization （TTV) on Diaphragm Function in Critically Ill Patients With Mechanical Ventilation: a Randomized Controlled Trial.
Who cites it
35 citing papers in PubMed, 5 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- Effectiveness of Nurse-Led Early Mobility Protocols on the Outcomes of Critical Care Patients: A Systematic Review and Meta-Analysis.Nursing open · 2025Pooled it
- Knowledge mapping and research trends on rehabilitation of patients with mechanical ventilation in the ICU from 2005 to 2024: a bibliometric analysis via CiteSpace and Bibliometrix.Frontiers in neurology · 2025Pooled it
- Liberation from mechanical ventilation in critically ill patients: Korean Society of Critical Care Medicine Clinical Practice Guidelines.Acute and critical care · 2024Guideline
- Pooled it
- Efficacy of Physiotherapy Interventions on Weaning in Mechanically Ventilated Critically Ill Patients: A Systematic Review and Meta-Analysis.Frontiers in medicine · 2022Pooled it
- Effects of protein, muscle rehabilitation and trunk neuromuscular electrostimulation in patients with prolonged mechanical ventilation: a prospective, randomized controlled pilot study.Annals of medicine · 2026Trial
- Electrical Impedance Tomography-Guided Synergistic Intervention of Respiratory Muscle Training and Postural Adjustment for Lung Recruitment in Critically Ill Patients With Respiratory Failure.Physiological research · 2026Trial
- Effect of neuromuscular electrical stimulation combined with early rehabilitation therapy on mechanically ventilated patients: a prospective randomized controlled study.BMC pulmonary medicine · 2023Trial
- ASSOBRAFIR clinical practice guidelines in intensive care physical therapy: Rehabilitation strategies in critically ill adults.Brazilian journal of physical therapy · 2026Review
- Respiratory Rehabilitation and Decannulation in Adults with Prolonged Mechanical Ventilation After Tracheostomy: A Narrative Review.Healthcare (Basel, Switzerland) · 2026Review
- Challenges in educating nursing students on mechanical ventilation: the case for interactive mobile learning tools - a randomized controlled trial.BMC nursing · 2026Article
- Perioperative nursing management of an adult patient with giant right-sided Bochdalek hernia: a case report.Frontiers in medicine · 2026Article
- Characteristic activation of respiratory muscles in Liuzijue practice: a preliminary study based on surface electromyography in healthy individuals.European journal of applied physiology · 2026Article
- Nurse-Led Early Mobility Protocols in the Intensive Care Unit.Nursing open · 2025Article
- Effect of Early and Progressive Rehabilitation Protocol on Fatigue, Functional Outcome, and Kinesiophobia in Patients on Non-invasive Ventilation: A Randomized Controlled Trial.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2025Article
- Diaphragm excursion difference as an adjunct predictor marker of postoperative pulmonary complications in video-assisted thoracoscopic surgery: a prospective, observational study.Journal of thoracic disease · 2025Article
- Multidisciplinary collaborative approach to cardiopulmonary rehabilitation in cancer patients with intensive care unit-acquired weakness: a clinical efficacy and safety analysis.American journal of cancer research · 2025Article
- An Early Rehabilitation Favors the Prognosis of Hypertensive Intracerebral Hemorrhage With Acute Disorders of Consciousness: A Retrospective Cohort Study With Propensity Score Matching.Neural plasticity · 2025Article
- Challenges in Transitioning from Controlled to Assisted Ventilation in Acute Respiratory Distress Syndrome (ARDS) Management.Journal of clinical medicine · 2024Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundProlonged mechanical ventilation (MV) induces diaphragm dysfunction in patients in the intensive care units (ICUs). Our study aimed to explore the therapeutic efficacy of early rehabilitation therapy in patients with prolonged MV in the ICU.
methodsEighty eligible patients who underwent MV for > 72 h in the ICU from June 2019 to March 2020 were enrolled in this prospective randomised controlled trial. The patients were randomly divided into a rehabilitation group (n = 39) and a control group (n = 41). Rehabilitation therapy included six levels of rehabilitation exercises. Diaphragm function was determined using ultrasound (US).
resultsDiaphragmatic excursion (DE) and diaphragm thickening fraction (DTF) were significantly decreased in all patients in both groups after prolonged MV (p < 0.001). The rehabilitation group had significantly higher DTF (p = 0.008) and a smaller decrease in DTF (p = 0.026) than the control group after 3 days of rehabilitation training. The ventilator duration and intubation duration were significantly shorter in the rehabilitation group than in the control group (p = 0.045 and p = 0.037, respectively). There were no significant differences in the duration of ICU stay, proportion of patients undergoing tracheotomy, and proportion of recovered patients between the two groups.
conclusionsEarly rehabilitation is feasible and beneficial to ameliorate diaphragm dysfunction induced by prolonged MV and advance withdrawal from the ventilator and extubation in patients with MV. Diaphragm US is suggested for mechanically ventilated patients in the ICU. Trial registration Chinese Clinical Trial Registry, ID: ChiCTR1900024046, registered on 2019/06/23.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.