ArticleNeuroImage. Clinical2021
Longitudinal fixel-based analysis reveals restoration of white matter alterations following balance training in young brain-injured patients.
Article in NeuroImage. Clinical, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.
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Who cites it
9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.
- Multimodal Analysis of Secondary Cerebellar Alterations After Pediatric Traumatic Brain Injury.JAMA network open · 2023Pooled it
- The second decade of DTI in TBI Part 2: a systematic review of moderate and severe TBI.Frontiers in neurologyPooled it
- Association Between Intraindividual Variability in Cognitive Performance and White Matter Organisation in Chronic Mild Traumatic Brain Injury.Human brain mapping · 2025Article
- Improving quantitative susceptibility mapping for the identification of traumatic brain injury neurodegeneration at the individual level.Zeitschrift fur medizinische Physik · 2025Article
- White matter alterations associated with chronic cannabis use disorder: a structural network and fixel-based analysis.Translational psychiatry · 2024Article
- ENIGMA's simple seven: Recommendations to enhance the reproducibility of resting-state fMRI in traumatic brain injury.NeuroImage. Clinical · 2024Review
- Fiber-specific structural properties relate to reading skills in children and adolescents.eLife · 2022Article
- White matter abnormalities characterize the acute stage of sports-related mild traumatic brain injury.Brain communications · 2022Article
- Intranasal delivery of interleukin-4 attenuates chronic cognitive deficits via beneficial microglial responses in experimental traumatic brain injury.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
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Authors and funding
6 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesTraumatic brain injury (TBI) is one of the leading causes of death and disability in children and adolescents. Young TBI patients suffer from gross motor deficits, such as postural control deficits, which can severely compromise their daily life activities. However, little attention has been devoted to uncovering the underlying white matter changes in response to training in TBI. In this study, we used longitudinal fixel-based analysis (FBA), an advanced diffusion imaging analysis technique, to investigate the effect of a balance training program on white matter fibre density and morphology in a group of young TBI patients.
methodsYoung patients with moderate-to-severe TBI (N = 17, 10 females, mean age = 13 ± 3 years) and age-matched controls (N = 17) underwent a home-based balance training program. Diffusion MRI scans together with gross motor assessments, including the gross motor items of the Bruininks-Oseretsky Test of Motor Proficiency, the Activities-Specific Balance Confidence (ABC) Scale, and the Sensory Organization Test (SOT) were administered before and at completion of 8-weeks of training. We used FBA to compare microstructural differences in fibre density (FD), macrostructural (morphological) changes in fibre cross-section (FC), and the combined FD and FC (FDC) metric across the whole brain. We then performed a longitudinal analysis to test whether training restores the white matter in the regions found to be damaged before treatment.
resultsWhole-brain fixel-based analysis revealed lower FD and FC in TBI patients compared to the control group across several commissural tracts, association fibres and projection fibres, with FD reductions of up to 50%. Following training, TBI patients showed a significant interaction effect between Group and Time for the SOT test, as well as significant increases in macrostructural white matter (i.e., FC & FDC) in left sensorimotor tracts. The amount of change in FC and FDC over time was, however, not associated with behavioural changes. DISCUSSION: Our fixel-based findings identified both microstructural and macrostructural abnormalities in young TBI patients. The longitudinal results provide a deeper understanding of the neurobiological mechanisms underlying balance training, which will allow clinicians to make more effective treatment decisions in everyday clinical practice with brain-injured patients.
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