Evidence map›Paper›PMID 33780745›Full record

ArticlePsychiatry research. Neuroimaging2021

Discrepancies of polygenic effects on symptom dimensions between adolescents and adults with ADHD.

Wenhao Jiang, Kelly Rootes-Murdy, Kuaikuai Duan, Gido Schoenmacker, Pieter J Hoekstra, Catharina A Hartman, Jaap Oosterlaan, Dirk Heslenfeld, Barbara Franke, Emma Sprooten and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychiatry research. Neuroimaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 8 institutions in 3 countries.

Wenhao JiangDepartment of Psychology, Georgia State University, United States; Department of Psychosomatics and Psychiatry, Zhongda Hospital, Institute of Psychosomatics, Medical School, Southeast University, Nanjing, China.
Kelly Rootes-MurdyDepartment of Psychology, Georgia State University, United States. Electronic address: krootesmurdy1@student.gsu.edu.
Kuaikuai DuanSchool of Electrical and Computer Engineering, Georgia Institute of Technology, USA.
Gido SchoenmackerDepartment of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands; Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands.
Pieter J HoekstraUniversity of Groningen, University Medical Center Groningen, Department of Psychiatry, Groningen, the Netherlands.
Catharina A HartmanUniversity of Groningen, University Medical Center Groningen, Department of Psychiatry, Groningen, the Netherlands.
Jaap OosterlaanEmma Children's Hospital, Amsterdam UMC, University of Amsterdam, Emma Neuroscience Group, department of Pediatrics, Amsterdam Reproduction & Development, Amsterdam, The Netherlands; Vrije Universiteit, Clinical Neuropsychology section, Van der Boechortstraat 7, 1081 BT Amsterdam, Netherlands.
Dirk HeslenfeldVrije Universiteit, Clinical Neuropsychology section, Van der Boechortstraat 7, 1081 BT Amsterdam, Netherlands.
Barbara FrankeDepartment of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands; Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands.
Emma SprootenDepartment of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands; Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands.
Jan BuitelaarDepartment of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands.
Alejandro Arias-VasquezDepartment of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands; Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands.
Jingyu LiuTri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology and Emory University, USA; Department of Computer Science, Georgia State University, USA.
Jessica A TurnerDepartment of Psychology, Georgia State University, United States; Tri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology and Emory University, USA; Neuroscience Institute, Georgia State University, USA.
Radboud University Nijmegen · NLCenter for Translational Research in Neuroimaging and Data Science · USGeorgia State University · USRadboud University Medical Center · NLUniversity of Groningen · NLEmma Kinderziekenhuis · NLGeorgia Institute of Technology · USVrije Universiteit Amsterdam · NL

Funding

International Multi-Center ADHD Genetics ProjectR01MH062873 · NIMH · UPSTATE MEDICAL UNIVERSITY · PI FARAONE, STEPHEN V · 2002 to 2007
$7.2M
Genetic Networks Influencing Gray Matter Changes in Persistent ADHDR01MH106655 · NIMH · THE MIND RESEARCH NETWORK · PI LIU, JINGYU · 2016 to 2019
$1.5M
NIMH NIH HHS R01 MH062873NIMH NIH HHS R01 MH106655
6 · The paper itself

Abstract

A significant proportion of individuals with attention-deficit/hyperactivity disorder (ADHD) show persistence into adulthood. The genetic and neural correlates of ADHD in adolescents versus adults remain poorly characterized. We investigated ADHD polygenic risk score (PRS) in relation to previously identified gray matter (GM) patterns, neurocognitive, and symptom findings in the same ADHD sample (462 adolescents & 422 adults from the NeuroIMAGE and IMpACT cohorts). Significant effects of ADHD PRS were found on hyperactivity and impulsivity symptoms in adolescents, hyperactivity symptom in adults, but not GM volume components. A distinct PRS effect between adolescents and adults on individual ADHD symptoms is suggested.

Indexed as

Attention Deficit Disorder with HyperactivityAdolescentAdultAttentionGray MatterHumansImpulsive BehaviorMultifactorial Inheritance

Identifiers

PMID33780745
PMCPMC8058322
OpenAlexW3138452148

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.