ReviewCurrent opinion in genetics & development2021
Making region-specific integumentary organs in birds: evolution and modifications.
Review in Current opinion in genetics & development, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- Adaptive Features of the Avian Integument: A Comparative Study of the Laughing Dove, Quail, Muscovy Duck, With Emphasis on the Preen Gland Secretions and Associated Microbial Communities.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2026Article
- Review
- Embryonic Avian Skin Explant Cultures: A Versatile Model for Investigating Tissue Patterning Mechanisms.The Journal of investigative dermatology · 2025Review
- Regulation of feather length: FGF/IGF signaling and NOTCH/YAP modulation of progenitor cell topology.Science advances · 2025Article
- Organizational principles of integumentary organs: Maximizing variations for effective adaptation.Developmental biology · 2025Review
- Skin regional specification and higher-orderScience advances · 2025Article
- Resilience of the replacing dentition in adult reptiles.Developmental biology · 2024Review
- Conserved regulatory switches for the transition from natal down to juvenile feather in birds.Nature communications · 2024Article
- Autofluorescence microscopy as a non-invasive probe to characterize the complex mechanical properties of keratin-based integumentary organs: A feather paradigm.Chinese journal of physics · 2023Article
- Transition from natal downs to juvenile feathers: conserved regulatory switches in Neoaves.Research square · 2023Article
- Evo Devo of the Vertebrates Integument.Journal of developmental biology · 2023Review
- Analysis and comparison of protein secondary structures in the rachis of avian flight feathers.PeerJ · 2022Article
- A quantitative image-based protocol for morphological characterization of cellular solids in feather shafts.STAR protocols · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Birds are the most diversified terrestrial vertebrates due to highly diverse integumentary organs that enable robust adaptability to various eco-spaces. Here we show that this complexity is built upon multi-level regional specifications. Across-the-body (macro-) specification includes the evolution of beaks and feathers as new integumentary organs that are formed with regional specificity. Within-an-organ (micro-) specification involves further modifications of organ shapes. We review recent progress in elucidating the molecular mechanisms underlying feather diversification as an example. (1) β-Keratin gene clusters are regulated by typical enhancers or high order chromatin looping to achieve macro- and micro-level regional specification, respectively. (2) Multi-level symmetry-breaking of feather branches confers new functional forms. (3) Complex color patterns are produced by combinations of macro-patterning and micro-patterning processes. The integration of these findings provides new insights toward the principle of making a robustly adaptive bio-interface.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.