Evidence map›Paper›PMID 33780664›Full record

ArticleEuropean journal of cancer (Oxford, England : 1990)2021

Seroprevalence of SARS-CoV-2 among the staff and patients of a French cancer centre after first lockdown: The canSEROcov study.

Sylvain Ladoire, Vincent Goussot, Emilie Redersdorff, Adele Cueff, Elise Ballot, Caroline Truntzer, Siavoshe Ayati, Leila Bengrine-Lefevre, Nathalie Bremaud, Bruno Coudert and 21 more

Open access · hybridAbstract read
In one paragraph

Article in European journal of cancer (Oxford, England : 1990), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.

  1. Pooled it
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  12. Taste loss as a distinct symptom of COVID-19: A systematic review and meta-analysis.medRxiv : the preprint server for health sciences · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors at 3 institutions in 1 country.

Sylvain LadoireDepartment of Medical Oncology, Centre Georges François Leclerc, Dijon, France; Research Platform in Biological Oncology, Georges François Leclerc Cancer Center, Dijon, France; Centre de Recherche INSERM LNC-UMR1231, Dijon, France; University of Burgundy-Franche Comté, France. Electronic address: sladoire@cgfl.fr.
Vincent GoussotDepartment of Pathology and Tumor Biology, Centre Georges François Leclerc, Dijon, France.
Emilie RedersdorffClinical Research Center (CRC), Centre Georges François Leclerc, Dijon, France.
Adele CueffMethodology and Biostatistics Unit, Centre Georges François Leclerc, Dijon, France.
Elise BallotResearch Platform in Biological Oncology, Georges François Leclerc Cancer Center, Dijon, France; Centre de Recherche INSERM LNC-UMR1231, Dijon, France; Bioinformatic Core Facility Georges, François Leclerc Cancer Center, Dijon, France.
Caroline TruntzerResearch Platform in Biological Oncology, Georges François Leclerc Cancer Center, Dijon, France; Centre de Recherche INSERM LNC-UMR1231, Dijon, France; Bioinformatic Core Facility Georges, François Leclerc Cancer Center, Dijon, France.
Siavoshe AyatiDepartment of Medical Oncology, Centre Georges François Leclerc, Dijon, France.
Leila Bengrine-LefevreDepartment of Medical Oncology, Centre Georges François Leclerc, Dijon, France.
Nathalie BremaudDepartment of Medical Oncology, Centre Georges François Leclerc, Dijon, France.
Bruno CoudertDepartment of Medical Oncology, Centre Georges François Leclerc, Dijon, France.
Isabelle DesmoulinsDepartment of Medical Oncology, Centre Georges François Leclerc, Dijon, France.
Laure FavierDepartment of Medical Oncology, Centre Georges François Leclerc, Dijon, France.
Cléa FraisseDepartment of Medical Oncology, Centre Georges François Leclerc, Dijon, France.
Jean-David FumetDepartment of Medical Oncology, Centre Georges François Leclerc, Dijon, France.
Roxana HanuDepartment of Medical Oncology, Centre Georges François Leclerc, Dijon, France.
Audrey HennequinDepartment of Medical Oncology, Centre Georges François Leclerc, Dijon, France.
Alice HervieuDepartment of Medical Oncology, Centre Georges François Leclerc, Dijon, France.
Silvia IlieDepartment of Medical Oncology, Centre Georges François Leclerc, Dijon, France.
Courèche KaderbhaiDepartment of Medical Oncology, Centre Georges François Leclerc, Dijon, France.
Aurélie LagrangeDepartment of Medical Oncology, Centre Georges François Leclerc, Dijon, France.
Nils MartinDepartment of Medical Oncology, Centre Georges François Leclerc, Dijon, France.
Irina MaziluDepartment of Medical Oncology, Centre Georges François Leclerc, Dijon, France.
Didier MayeurDepartment of Medical Oncology, Centre Georges François Leclerc, Dijon, France.
Rémi PalmierDepartment of Medical Oncology, Centre Georges François Leclerc, Dijon, France.
Anne-Laure Simonet-LammDepartment of Medical Oncology, Centre Georges François Leclerc, Dijon, France.
Julie VincentDepartment of Medical Oncology, Centre Georges François Leclerc, Dijon, France.
Sylvie ZanettaDepartment of Medical Oncology, Centre Georges François Leclerc, Dijon, France.
Laurent ArnouldResearch Platform in Biological Oncology, Georges François Leclerc Cancer Center, Dijon, France; Department of Pathology and Tumor Biology, Centre Georges François Leclerc, Dijon, France.
Charles CoutantUniversity of Burgundy-Franche Comté, France; Department of Oncologic Surgery, Centre Georges François Leclerc, Dijon, France.
Aurélie BertautMethodology and Biostatistics Unit, Centre Georges François Leclerc, Dijon, France.
François GhiringhelliDepartment of Medical Oncology, Centre Georges François Leclerc, Dijon, France; Research Platform in Biological Oncology, Georges François Leclerc Cancer Center, Dijon, France; Centre de Recherche INSERM LNC-UMR1231, Dijon, France; University of Burgundy-Franche Comté, France.
Centre Georges François Leclerc · FRInserm · FRUniversité de Bourgogne · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn view of the potential gravity of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection for patients with cancer, epidemiological data are vital to assess virus circulation among patients and staff of cancer centres. We performed a prospective study to investigate seroprevalence of SARS-CoV-2 antibodies among staff and patients with cancer at a large cancer centre, at the end of the period of first national lockdown in France and to determine factors associated with the risk of SARS-CoV-2 infection.

methodsAfter the first lockdown, all medical and non-medical staff, as well as all patients attending the medical oncology department were invited to undergo serological testing for SARS-CoV-2 between 11 May and 30 June 2020. All participants were also invited to complete a questionnaire collecting data about their living and working conditions, and for patients, medical management during lockdown.

findingsA total of 1,674 subjects (663 staff members, 1011 patients) were included. Seroprevalence was low in both staff (1.8%) and patients (1.7%), despite more features of high risk for severe forms among patients. None of the risk factors tested in our analysis (working or living conditions, comorbidities, management characteristics during lockdown) was found to be statistically associated with seroprevalence in either staff or patients. There was no significant difference in the proportion of symptomatic and asymptomatic subjects between staff and patients. Only fever, loss of smell, and loss of taste were significantly more frequent among seropositive patients, in both staff and patients.

interpretationWe report very low seroprevalence of antibodies against SARS-CoV-2 in the staff (caregiving and non-caregiving) and patients of a large cancer care centre in which strict hygiene, personal protection, and social distancing measures were implemented.

Indexed as

Cancer Care FacilitiesAdolescentAdultAgedAged, 80 and overCarrier StateChildChild, PreschoolCOVID-19COVID-19 Serological TestingFemaleFranceHealth PersonnelHumansMaleMiddle AgedAntibodyCancer centerCancer patientsCOVID-19Healthcare workersSARS-COV-2SerodiagnosisSerologySeroprevalenceStaff

Identifiers

PMID33780664
PMCPMC7914029
OpenAlexW3135219309

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.