Evidence map›Paper›PMID 33780526›Full record

ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2021

Short Physical Performance Battery as a Crosswalk Between Frailty Phenotype and Deficit Accumulation Frailty Index.

Hee-Won Jung, Ji Yeon Baek, Il-Young Jang, Jack M Guralnik, Kenneth Rockwood, Eunju Lee, Dae Hyun Kim

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04962841 (Cognitive and Physical Impairment in Frail Older Adults), which is not on this map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04962841 unknown statusnot on this map

Cognitive and Physical Impairment in Frail Older Adults

TypeobservationalSponsorUniversity of Campania Luigi VanvitelliRan2020 to 2023Enrolled485ConditionsFrailtyArmsNutraceuticals
3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 33 citations in OpenAlex.

  1. [Effects of Exercise Training Combined With β-Hydroxy-β-Methylbutyrate Supplementation on Physical Function in Older Adults With Frailty].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026
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  20. Frailty as a Clinically Relevant Measure of Human Aging.Annals of geriatric medicine and research · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Hee-Won JungDivision of Geriatrics, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.ORCID 0000-0002-2583-3354
Ji Yeon BaekDivision of Geriatrics, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Il-Young JangDivision of Geriatrics, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.ORCID 0000-0003-3617-3301
Jack M GuralnikDivision of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, USA.
Kenneth RockwoodDivisions of Geriatric Medicine & Neurology, Dalhousie University and Nova Scotia Health, Halifax, Canada.ORCID 0000-0002-6674-995X
Eunju LeeDivision of Geriatrics, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Dae Hyun KimMarcus Institute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts, USA.ORCID 0000-0001-7290-6838
Ulsan College · KRBeth Israel Deaconess Medical Center · USDalhousie University · CAUniversity of Maryland, Baltimore · US

Funding

Prospective Monitoring of Newly Approved Cardiovascular Drugs in Older Adults with FrailtyR01AG062713 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI KIM, DAE HYUN · 2019 to 2022
$2.8M
CIHR PJT-156114NIA NIH HHS R01 AG062713NIH HHS R01AG062713
6 · The paper itself

Abstract

backgroundGrowing evidence supports the clinical importance of evaluating frailty in older adults, with its strong outcome relevance. We aimed to assess whether the Short Physical Performance Battery (SPPB) correlates with frailty status according to phenotype and deficit accumulation models and can be used as a link between these models.

methodsWe analyzed records of 1064 individuals from the Aging Study of Pyeongchang Rural Area, a population-based, prospective cohort from South Korea. Frailty was determined using the Cardiovascular Health Study (CHS) phenotype (phenotype model), 26- and 34-item frailty indices (deficit accumulation model). Associations of SPPB score and frailty with a composite outcome of mortality or long-term institutionalization were assessed. Crosswalks for SPPB, the CHS frailty phenotype, and the frailty index were created.

resultsThe mean age of the study population was 76.0 years, and 583 (54.8%) were women. According to the CHS phenotype, 26- and 34-item frailty indices, 242 (22.7%), 161 (15.1%), and 280 (26.3%) participants, respectively, had frailty. Sensitivities/specificities for classifying CHS phenotype, 26- and 34-item frailty indices were 0.93/0.55, 0.71/0.84, and 0.80/0.83 by SPPB cut points of ≤9, ≤6, and ≤7, respectively. C-index of SPPB score (0.78) showed a predictive ability for the composite outcome that was comparable to that of CHS frailty phenotype (0.79), 26- (0.78), and 34-item frailty indices (0.79).

conclusionsWe could create a crosswalk linking frailty phenotype and frailty index from correlations between SPPB and frailty models. This result may facilitate clinical adoption of the frailty concept in a broader spectrum of older adults.

Indexed as

FrailtyGeriatric AssessmentPhysical Functional PerformanceAgedFemaleHumansMalePhenotypeProspective StudiesFrailtyFunctional performancePhysical performance

Identifiers

PMID33780526
PMCPMC8598989
OpenAlexW3149348278

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.