Evidence map›Paper›PMID 33780433›Full record

ArticlePLoS computational biology2021

Vocalization with semi-occluded airways is favorable for optimizing sound production.

Ingo R Titze, Anil Palaparthi, Karin Cox, Amanda Stark, Lynn Maxfield, Brian Manternach

Registry-linked trialAbstract read
In one paragraph

Article in PLoS computational biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06934265 (Phonation Resistance Training Exercises), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06934265 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Phonation Resistance Training Exercises (PhoRTE®) Delivered In-person and Via Telehealth: A Noninferiority Randomized Clinical Trial

TypeinterventionalSponsorUniversity of Southern CaliforniaRan2026 to 2026Enrolled30ConditionsAtrophy of Vocal Cord, Presbyphonia, Dysphonia, Glottic InsufficiencyArmsexuberant voice therapy
3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Comparative Study of Two Semi-Occluded Vocal Tract Protocols: A Randomized Clinical Trial.Journal of speech, language, and hearing research : JSLHR · 2024
    Trial
  2. Optimizing Diameter, Length, and Water Immersion in Flow Resistant Tube Vocalization.Journal of voice : official journal of the Voice Foundation · 2025
    Article
  3. Article
  4. Characterization of upper esophageal sphincter pressures relative to vocal acoustics.Journal of applied physiology (Bethesda, Md. : 1985) · 2025
    Article
  5. Pressure Distributions in Glottal Geometries With Multichannel Airflows.Journal of voice : official journal of the Voice Foundation · 2024
    Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ingo R TitzeNational Center for Voice and Speech University of Utah, Salt Lake City, Utah, United States of America.ORCID 0000-0002-0148-0750
Anil PalaparthiNational Center for Voice and Speech University of Utah, Salt Lake City, Utah, United States of America.ORCID 0000-0003-4273-9113
Karin CoxNational Center for Voice and Speech.Org, Salt Lake City, Utah, United States of America.ORCID 0000-0003-4932-4527
Amanda StarkNational Center for Voice and Speech University of Utah, Salt Lake City, Utah, United States of America.
Lynn MaxfieldNational Center for Voice and Speech University of Utah, Salt Lake City, Utah, United States of America.
Brian ManternachNational Center for Voice and Speech University of Utah, Salt Lake City, Utah, United States of America.ORCID 0000-0002-2875-5005

Funding

Voice Therapy with Semi-Occluded Vocal TractsR01DC013573 · NIDCD · UNIVERSITY OF UTAH · PI TITZE, INGO R · 2014 to 2018
$2.5M
NIDCD NIH HHS R01 DC013573
6 · The paper itself

Abstract

Vocalization in mammals, birds, reptiles, and amphibians occurs with airways that have wide openings to free-space for efficient sound radiation, but sound is also produced with occluded or semi-occluded airways that have small openings to free-space. It is hypothesized that pressures produced inside the airway with semi-occluded vocalizations have an overall widening effect on the airway. This overall widening then provides more opportunity to produce wide-narrow contrasts along the airway for variation in sound quality and loudness. For human vocalization described here, special emphasis is placed on the epilaryngeal airway, which can be adjusted for optimal aerodynamic power transfer and for optimal acoustic source-airway interaction. The methodology is three-fold, (1) geometric measurement of airway dimensions from CT scans, (2) aerodynamic and acoustic impedance calculation of the airways, and (3) simulation of acoustic signals with a self-oscillating computational model of the sound source and wave propagation.

Indexed as

PharynxTracheaBiomechanical PhenomenaFemaleHumansMaleModels, BiologicalSound SpectrographySpeechSpeech Acoustics

Identifiers

PMID33780433
PMCPMC8031921

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.