Evidence map›Paper›PMID 33780131›Full record

ArticleMicrobial biotechnology2022

Armeniaspirol A: a novel anti-Helicobacter pylori agent.

Jia Jia, Chongwen Zhang, Yaqi Liu, Yanqiang Huang, Yuefan Bai, Xudong Hang, Liping Zeng, Dongqing Zhu, Hongkai Bi

Open access · goldAbstract read
In one paragraph

Article in Microbial biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 41 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Overcoming antibiotic-resistantWorld journal of gastroenterology · 2025
    Review
  7. Fighting Antimicrobial Resistance: Innovative Drugs in Antibacterial Research.Angewandte Chemie (International ed. in English) · 2025
    Review
  8. Diseases (Basel, Switzerland) · 2024
    Review
  9. Molecular Mechanisms of Biofilm Formation inAntibiotics (Basel, Switzerland) · 2024
    Review
  10. Discovery of Cinnamic Acid Derivatives as Potent Anti-Molecules (Basel, Switzerland) · 2024
    Article
  11. Article
  12. Loureirin A is a narrow-spectrum antimicrobial agent againstAntimicrobial agents and chemotherapy · 2024
    Article
  13. Article
  14. Article
  15. Review
  16. Biofilm ofAntibiotics (Basel, Switzerland) · 2023
    Review
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Jia JiaDepartment of Pathogen Biology & Jiangsu Key Laboratory of Pathogen Biology & Helicobacter pylori Research Centre, Nanjing Medical University, Nanjing, Jiangsu, 211166, China.
Chongwen ZhangDepartment of Pathogen Biology & Jiangsu Key Laboratory of Pathogen Biology & Helicobacter pylori Research Centre, Nanjing Medical University, Nanjing, Jiangsu, 211166, China.
Yaqi LiuKey Laboratory of Combinatorial Biosynthesis and Drug Discovery Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, Wuhan, Hubei, 430071, China.
Yanqiang HuangDepartment of Pathogen Biology & Jiangsu Key Laboratory of Pathogen Biology & Helicobacter pylori Research Centre, Nanjing Medical University, Nanjing, Jiangsu, 211166, China.
Yuefan BaiDepartment of Pathogen Biology & Jiangsu Key Laboratory of Pathogen Biology & Helicobacter pylori Research Centre, Nanjing Medical University, Nanjing, Jiangsu, 211166, China.
Xudong HangDepartment of Pathogen Biology & Jiangsu Key Laboratory of Pathogen Biology & Helicobacter pylori Research Centre, Nanjing Medical University, Nanjing, Jiangsu, 211166, China.
Liping ZengDepartment of Pathogen Biology & Jiangsu Key Laboratory of Pathogen Biology & Helicobacter pylori Research Centre, Nanjing Medical University, Nanjing, Jiangsu, 211166, China.
Dongqing ZhuKey Laboratory of Combinatorial Biosynthesis and Drug Discovery Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, Wuhan, Hubei, 430071, China.
Hongkai BiDepartment of Pathogen Biology & Jiangsu Key Laboratory of Pathogen Biology & Helicobacter pylori Research Centre, Nanjing Medical University, Nanjing, Jiangsu, 211166, China.ORCID 0000-0003-0085-6602
Nanjing Medical University · CNWuhan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antibiotic resistance in Helicobacter pylori has been growing worldwide with current treatment regimens. Development of new compounds for treatment of H. pylori infections is urgently required to achieve a successful eradication therapy in the future. Armeniaspirols, a novel class of natural products isolated from Streptomyces armeniacus, have been previously identified as antibacterial agents against Gram-positive pathogens. In this study, we found that armeniaspirol A (ARM1) exhibited potent antibacterial activity against H. pylori, including multidrug-resistant strains, with MIC range values of 4-16 μg ml

Indexed as

Helicobacter InfectionsHelicobacter pyloriAnimalsAnti-Bacterial AgentsMetronidazoleMicePyrrolesSpiro CompoundsAnti-Bacterial Agentsarmeniaspirol AMetronidazolePyrrolesSpiro Compounds

Identifiers

PMID33780131
PMCPMC8867979
OpenAlexW3150114898

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.