SynthesisNeuropsychology review2021
Sleep Disorders and Cognitive Dysfunctions in Parkinson's Disease: A Meta-Analytic Study.
Synthesis in Neuropsychology review, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 4 of them syntheses that pooled it.
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The trial behind it
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Who cites it
47 citing papers in PubMed, 4 syntheses or guidelines pooled it, 70 citations in OpenAlex.
- Effects of different frequencies of repetitive transcranial magnetic stimulation on sleep disorders and depression in patients with Parkinson's disease: a systematic review and network meta-analysis.Frontiers in aging neuroscience · 2025Pooled it
- Summary of the best evidence for non-pharmaceutical interventions for mild cognitive impairment in Parkinson's disease.Frontiers in neurology · 2025Pooled it
- Pooled it
- Prevalence and clinical aspects of obstructive sleep apnea in Parkinson disease: A meta-analysis.European journal of neurology · 2024Pooled it
- The Relevance of Sleep Quality for Clinical Care in Parkinson's Disease: Clinical and Cognitive Differences Between Good and Poor Sleepers: A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2026Article
- Article
- The inflammation-nutrition axis and survival outcomes: Role of the neutrophil percentage-to-albumin ratio in patients with sleep disorders.The Journal of international medical research · 2026Article
- The Effect of Deep Brain Stimulation on Sleep and Cognition in Patients With Parkinson's Disease.Journal of sleep research · 2026Article
- Wakefulness regulation of memory encoding and retrieval: structure and activity.National science review · 2026Review
- Exploring the Active Ingredients and Core Targets of Erxia Decoction in the Treatment of Sleep Disorder by Integration of Network Pharmacology and Proteomics.Combinatorial chemistry & high throughput screening · 2026Article
- Exploring biomechanical differences between brain-first and body-first Parkinson's disease subtypes using shear wave elastography: a pilot cross-sectional study.Frontiers in aging neuroscience · 2026Article
- Associations between risk of obstructive sleep apnea and cognitive performance In Parkinson's disease: evidence from the Canadian Longitudinal Study on Aging.Sleep & breathing = Schlaf & Atmung · 2025Article
- Restless legs syndrome in Parkinson's disease: epidemiology, pathogenetic overlaps, and clinical management.Journal of neurology · 2025Review
- Multi-cohort machine learning identifies predictors of cognitive impairment in Parkinson's disease.NPJ digital medicine · 2025Article
- Meta-analysis of the prevalence of obstructive sleep apnea and associated risk factors among Parkinson's disease.Sleep and biological rhythms · 2025Review
- Ecological and Demographic Influences on the Prevalence of Sleep Disorders and Their Impact on Cognitive Decline.Cureus · 2025Article
- From Night to Light: A Bibliometric Analysis of the Global Research Trajectory of Sleep Disorders in Parkinson's Disease.Journal of multidisciplinary healthcare · 2025Article
- Factors associated with sleep disorders in elderly patients with Parkinson's disease and cognitive impairment and the nomogram model development.Frontiers in aging neuroscience · 2025Article
- ModFus-PD: synergizing cross-modal attention and contrastive learning for enhanced multimodal diagnosis of Parkinson's disease.Frontiers in computational neuroscience · 2025Article
- Acupuncture as an adjunctive therapy for sleep fragmentation in Parkinson's disease: a pilot study based on polysomnography.Frontiers in neurology · 2025Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A relationship between sleep disorders and cognitive dysfunctions was reported in Parkinson's Disease (PD), however, some studies did not confirm the link. A meta-analytic study was performed to investigate the relationship between sleep disorders and cognitive dysfunctions, and to clarify the evolution of cognitive status in PD patients with sleep disorders.The systematic literature search was performed up to November 2020 using PubMed, Scopus, and PsycINFO databases. We included studies published in peer-reviewed journals in English providing results about neuropsychological comparison between patients with or without sleep disorders. Meta-analysis on cross-sectional data included 54 studies for REM Sleep Behavior Disorder (RBD), 22 for Excessive Daytime Sleepiness (EDS), 7 for Obstructive Sleep Apnea (OSA), 13 for Restless Legs Syndrome (RLS), and 5 for insomnia, the meta-analysis on longitudinal data included 7 studies.RBD was related to deficits of global cognitive functioning, memory, executive functions, attention/working memory, language, and visuospatial abilities. EDS was associated with deficits of global cognitive functioning and attention and working memory abilities, whereas RLS and OSA were related to global cognitive dysfunction. Moreover, we revealed that PD patients with RBD and those with EDS performed worse than PD patients without sleep disorders at follow-up rather than baseline evaluation. Our results suggest that sleep disorders are associated with cognitive deficits supporting indirectly that these, especially the REM Sleep Behavior Disorder, reflect abnormalities of frontal networks and posterior cortical areas. Sleep disorders in patients with PD seem to also increase the risk for long-term cognitive decline.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.