Evidence map›Paper›PMID 33779841›Full record

ReviewJournal of neurology2022

Opsoclonus-myoclonus-ataxia syndrome in children.

Poonam Bhatia, Jennifer Heim, Patricia Cornejo, Lauren Kane, Jason Santiago, Michael C Kruer

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 45 citations in OpenAlex.

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  19. Article
  20. Adult-onset idiopathic opsoclonus-myoclonus syndrome.Arquivos brasileiros de oftalmologia · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Poonam BhatiaPediatric Movement Disorders Program, Barrow Neurological Institute, Phoenix Children's Hospital, 1919 E Thomas Rd, Phoenix, AZ, 85016, USA.
Jennifer HeimPediatric Movement Disorders Program, Barrow Neurological Institute, Phoenix Children's Hospital, 1919 E Thomas Rd, Phoenix, AZ, 85016, USA.
Patricia CornejoDepartment of Radiology, Phoenix Children's Hospital, Phoenix, AZ, USA.
Lauren KanePediatric Movement Disorders Program, Barrow Neurological Institute, Phoenix Children's Hospital, 1919 E Thomas Rd, Phoenix, AZ, 85016, USA.
Jason SantiagoPediatric Movement Disorders Program, Barrow Neurological Institute, Phoenix Children's Hospital, 1919 E Thomas Rd, Phoenix, AZ, 85016, USA.
Michael C KruerPediatric Movement Disorders Program, Barrow Neurological Institute, Phoenix Children's Hospital, 1919 E Thomas Rd, Phoenix, AZ, 85016, USA. mkruer@phoenixchildrens.com.ORCID http://orcid.org/0000-0002-1373-7891
Barrow Neurological Institute · USPhoenix Children's Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Opsoclonus-myoclonus-ataxia syndrome is a rare neuroimmunologic disorder typically presenting in previously healthy infants and toddlers. It is characterized by a clinical triad of (1) erratic saccadic intrusions; (2) myoclonus and/or ataxia; (3) behavioral features, typified by developmental plateauing, irritability and insomnia. About half of cases are associated with an underlying neuroblastoma and diagnostic imaging is essential once OMAS is suspected. A thorough workup, including serum, urine, and cerebrospinal fluid studies is critical to identify underlying biomarkers of OMAS itself or neuroblastoma. Historically, many children had relatively poor long-term outcomes, with residual neurologic and/or neuropsychiatry sequelae typical. More recent concepts have emphasized combined immunotherapy regimens that offer hope for better outcomes in children with this remarkable, challenging disease.

Indexed as

NeuroblastomaOcular Motility DisordersOpsoclonus-Myoclonus SyndromeAtaxiaDisease ProgressionHumansInfantMovement disordersNeuroimmunologyOpsoclonus–myoclonus–ataxiaPediatric

Identifiers

PMID33779841
OpenAlexW3149690364

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.