Evidence map›Paper›PMID 33779562›Full record

ReviewComparative biochemistry and physiology. Part B, Biochemistry & molecular biology

Utilizing comparative models in biomedical research.

Alexander G Little, Matthew E Pamenter, Divya Sitaraman, Nicole M Templeman, William G Willmore, Michael S Hedrick, Christopher D Moyes

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Alexander G LittleDepartment of Biology, Queen's University, Kingston, Canada.
Matthew E PamenterDepartment of Biology, University of Ottawa, Ottawa, Canada.
Divya SitaramanDepartment of Psychology, California State University, East Bay, Hayward, CA, USA.
Nicole M TemplemanDepartment of Biology, University of Victoria, Victoria, Canada.
William G WillmoreInstitute of Biochemistry, Carleton University, Ottawa, Canada.
Michael S HedrickDepartment of Biological Sciences, California State University, East Bay, Hayward, CA, USA.
Christopher D MoyesDepartment of Biology, Queen's University, Kingston, Canada. Electronic address: chris.moyes@queensu.ca.
California State University, East Bay · USQueen's University · CACarleton University · CAUniversity of Ottawa · CAUniversity of Victoria · CA

Funding

Dopamine regulation of sleep and arousalR15GM125073 · NIGMS · UNIVERSITY OF SAN DIEGO · PI SITARAMAN, DIVYA · 2017 to 2025
$951k
NIGMS NIH HHS R15 GM125073
6 · The paper itself

Abstract

This review serves as an introduction to a Special Issue of Comparative Biochemistry and Physiology, focused on using non-human models to study biomedical physiology. The concept of a model differs across disciplines. For example, several models are used primarily to gain an understanding of specific human pathologies and disease states, whereas other models may be focused on gaining insight into developmental or evolutionary mechanisms. It is often the case that animals initially used to gain knowledge of some unique biochemical or physiological process finds foothold in the biomedical community and becomes an established model. The choice of a particular model for biomedical research is an ongoing process and model validation must keep pace with existing and emerging technologies. While the importance of non-mammalian models, such as Caenorhabditis elegans, Drosophila melanogaster, Danio rerio and Xenopus laevis, is well known, we also seek to bring attention to emerging alternative models of both invertebrates and vertebrates, which are less established but of interest to the comparative biochemistry and physiology community.

Indexed as

Biomedical ResearchModels, BiologicalAnimalsCaenorhabditis elegansDrosophila melanogasterXenopus laevisZebrafish

Identifiers

PMID33779562
PMCPMC8906884
OpenAlexW3138459808

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.