ArticleeLife2021
Disparate bone anabolic cues activate bone formation by regulating the rapid lysosomal degradation of sclerostin protein.
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Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
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Who cites it
26 citing papers in PubMed, 35 citations in OpenAlex.
- Fracture healing: from molecular and cellular mechanisms to therapeutic strategies.Signal transduction and targeted therapy · 2026Review
- Exercise-responsive crosstalk within local muscle-bone units in osteosarcopenia: from mechanotransduction to secretome signalling.Frontiers in physiology · 2026Review
- Inhibition or genetic reduction of ASAH1/acid ceramidase restore α-synuclein clearance in mutant GBA1 dopamine neurons from Parkinson's patients.Human molecular genetics · 2025Article
- Elevation of master autophagy regulator Tfeb in osteoblast lineage cells increases bone mass and strength.JCI insight · 2025Article
- Mechanosignaling in Osteoporosis: When Cells Feel the Force.International journal of molecular sciences · 2025Review
- Melanoma bone metastasis-induced osteocyte ferroptosis via the HIF1α-HMOX1 axis.Bone research · 2025Article
- Localized sclerostin accumulation in osteocyte lacunar-canalicular system is associated with cortical bone microstructural alterations and bone fragility inFrontiers in cell and developmental biology · 2025Article
- Article
- Nitric oxide contributes to rapid sclerostin protein loss following mechanical load.Biochemical and biophysical research communications · 2024Article
- Machine Learning-Driven Biomarker Discovery for Skeletal Complications in Type 1 Gaucher Disease Patients.International journal of molecular sciences · 2024Article
- Article
- Osteocyte-mediated mechanical response controls osteoblast differentiation and function.Frontiers in physiology · 2024Review
- Osteoblast-lineage calcium/calmodulin-dependent kinase 2 delta and gamma regulates bone mass and quality.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Connexin 43 and cell culture substrate differentially regulate OCY454 osteocytic differentiation and signaling to primary bone cells.American journal of physiology. Cell physiology · 2023Article
- Acid ceramidase involved in pathogenic cascade leading to accumulation of α-synuclein in iPSC model of GBA1-associated Parkinson's disease.Human molecular genetics · 2023Article
- Importance of Sclerostin as Bone-Muscle Mediator Crosstalk.Annals of geriatric medicine and research · 2022Article
- Positive and Negative Regulators of Sclerostin Expression.International journal of molecular sciences · 2022Review
- Wnt signaling pathway inhibitors, sclerostin and DKK-1, correlate with pain and bone pathology in patients with Gaucher disease.Frontiers in endocrinology · 2022Article
- Effect of adrenocorticotropic hormone infusion on circulating sclerostin levels.Endocrine connections · 2021Article
- Article
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Nicole R GouldDepartment of Orthopaedics, University of Maryland School of Medicine, Baltimore, United States.
Katrina M WilliamsDepartment of Orthopaedics, University of Maryland School of Medicine, Baltimore, United States.ORCID http://orcid.org/0000-0003-3729-0630
Humberto C JocaCenter for Biomedical Engineering and Technology, University of Maryland School of Medicine, Baltimore, United States.
Olivia M TorreDepartment of Orthopaedics, University of Maryland School of Medicine, Baltimore, United States.ORCID http://orcid.org/0000-0003-3405-6259
James S LyonsDepartment of Orthopaedics, University of Maryland School of Medicine, Baltimore, United States.
Jenna M LeserDepartment of Orthopaedics, University of Maryland School of Medicine, Baltimore, United States.
Manasa P SrikanthDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, United States.
Marcus HughesDepartment of Orthopaedics, University of Maryland School of Medicine, Baltimore, United States.
Ramzi J KhairallahMyologica, LLC, New Market, United States.
Ricardo A FeldmanDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, United States.
Christopher W WardDepartment of Orthopaedics, University of Maryland School of Medicine, Baltimore, United States.
Joseph P StainsDepartment of Orthopaedics, University of Maryland School of Medicine, Baltimore, United States.ORCID https://orcid.org/0000-0002-1610-4694
University of Maryland, Baltimore · US
Funding
Interdisciplinary Training Program Muscle BiologyT32AR007592 · NIAMS · UNIVERSITY OF MARYLAND BALTIMORE · PI Aikaterini Kontrogianni-Konstantopoulos · 1996 to 2026
$11.7MTranslational Imaging and Phenotyping CoreP30AR075042 · NIAMS · MASSACHUSETTS GENERAL HOSPITAL · PI Marie Demay · 2019 to 2026
$7.4MTRAINING PROGRAM IN INTEGRATIVE MEMBRANE BIOLOGYT32GM008181 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE · PI RIZZO, MEGAN A, TRUDEAU, MATTHEW C · 1987 to 2022
$4.9MSpatial Control of Bone Remodeling by Gap Junction-Communicated cAMPR01AR063631 · NIAMS · UNIVERSITY OF MARYLAND BALTIMORE · PI STAINS, JOSEPH P. · 2013 to 2024
$3.3MChemo-mechanical signaling in atrial myocytesR01HL142290 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI LEDERER, WILLIAM JONATHAN, WARD, CHRISTOPHER WILLIAM · 2019 to 2022
$2.6MMicrotubule Regulated Mechanotransduction in Skeletal MuscleR01AR071618 · NIAMS · UNIVERSITY OF MARYLAND BALTIMORE · PI WARD, CHRISTOPHER WILLIAM · 2017 to 2021
$2.6MOsteocyte CaMKII as a Critical Regulator of Bone Physiology and AnabolismR01AR071614 · NIAMS · UNIVERSITY OF MARYLAND BALTIMORE · PI Joseph P. Stains · 2018 to 2026
$2.6MOsteocyte CaMKII as a Critical Regulator of Bone Physiology AnabolismR56AR071614 · NIAMS · UNIVERSITY OF MARYLAND BALTIMORE · PI STAINS, JOSEPH P. · 2024 to 2024
$230kNHLBI NIH HHS R01 HL142290NIAMS NIH HHS P30 AR075042NIAMS NIH HHS R01 AR063631NIAMS NIH HHS R01 AR071614NIAMS NIH HHS R01 AR071618NIAMS NIH HHS R56 AR071614NIAMS NIH HHS T32 AR007592NIGMS NIH HHS T32 GM008181NIH HHS AR007592
Abstract
The downregulation of sclerostin in osteocytes mediates bone formation in response to mechanical cues and parathyroid hormone (PTH). To date, the regulation of sclerostin has been attributed exclusively to the transcriptional downregulation of the
Indexed as
Adaptor Proteins, Signal TransducingAnimalsBone and BonesBone Morphogenetic ProteinsCell LineCuesDown-RegulationFemaleGaucher DiseaseGenetic MarkersHumansLysosomesMaleMiceMice, Inbred C57BLOsteocytesAdaptor Proteins, Signal TransducingBone Morphogenetic ProteinsGenetic MarkersParathyroid HormoneSOST protein, humanSost protein, mouseSost protein, ratbonecell biologylysosomemechanical loadmouseosteocyteparathyroid hormonesclerostin
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.