Evidence map›Paper›PMID 33779531›Full record

ArticleAmerican journal of respiratory and critical care medicine2021

Benefits of Airway Androgen Receptor Expression in Human Asthma.

Joe G Zein, Jeffrey M McManus, Nima Sharifi, Serpil C Erzurum, Nadzeya Marozkina, Timothy Lahm, Olivia Giddings, Michael D Davis, Mark D DeBoer, Suzy A Comhair and 19 more

Open access · greenAbstract read
In one paragraph

Article in American journal of respiratory and critical care medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Androgens are a Key Factor Affecting Immune Related Diseases.The world journal of men's health · 2026
    Review
  4. Article
  5. Article
  6. Review
  7. Sex, hormones, and lung health.Physiological reviews · 2026
    Review
  8. Sex Differences in Asthma Pathogenesis.Immunological reviews · 2026
    Review
  9. αThe journal of allergy and clinical immunology. In practice · 2025
    Article
  10. Association between orchiectomy and asthma: Insights from 2 population-based cohorts.The journal of allergy and clinical immunology. Global · 2025
    Article
  11. Article
  12. Article
  13. Asthma Inception: Epidemiologic Risk Factors and Natural History Across the Life Course.American journal of respiratory and critical care medicine · 2024
    Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. A Between-Sex Comparison of the Genomic Architecture of Asthma.American journal of respiratory cell and molecular biology · 2023
    Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

29 authors at 16 institutions in 2 countries.

Joe G ZeinLerner Research Institute and.
Jeffrey M McManusLerner Research Institute and.
Nima SharifiLerner Research Institute and.
Serpil C ErzurumLerner Research Institute and.
Nadzeya MarozkinaDepartment of Pediatrics.
Timothy LahmDepartment of Medicine, and.
Olivia GiddingsDepartment of Pediatrics and.
Michael D DavisDepartment of Pediatrics.
Mark D DeBoerDepartment of Pediatrics, University of Virginia, Charlottesville, Virginia.
Suzy A ComhairLerner Research Institute and.
Peter BazeleyLerner Research Institute and.
Hyun Jo KimDepartment of Systems Biology and Bioinformatics, Case Western Reserve University, Cleveland, Ohio.
William BusseDepartment of Medicine, School of Medicine, University of Wisconsin, Madison, Wisconsin.
William CalhounDepartment of Medicine, University of Texas Medical Branch, University of Texas, Galveston, Texas.
Mario CastroDivision of Pulmonary, Critical Care, and Sleep Medicine, School of Medicine, University of Kansas, Kansas City, Kansas.
Kian Fan ChungNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
John V FahyDivision of Pulmonary, Critical Care, and Sleep Medicine, School of Medicine, University of Kansas, Kansas City, Kansas.
Elliot IsraelDivision of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital and Harvard Medical School, Harvard University, Boston, Massachusetts.
Nizar N JarjourDepartment of Medicine, School of Medicine, University of Wisconsin, Madison, Wisconsin.
Bruce D LevyDivision of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital and Harvard Medical School, Harvard University, Boston, Massachusetts.ORCID 0000-0001-9515-5731
David T MaugerCenter for Biostatistics and Epidemiology, School of Medicine, Pennsylvania State University, Hershey, Pennsylvania.
Wendy C MooreSection on Pulmonary, Critical Care, Allergic, and Immunologic Disease, Department of Internal Medicine, School of Medicine, Wake Forest University, Winston-Salem, North Carolina.
Victor E OrtegaSection on Pulmonary, Critical Care, Allergic, and Immunologic Disease, Department of Internal Medicine, School of Medicine, Wake Forest University, Winston-Salem, North Carolina.
Michael PetersDivision of Pulmonary and Critical Care Medicine, Department of Medicine, University of California at San Francisco, San Francisco, California.
Eugene R BleeckerDivision of Genetics, Genomics, and Precision Medicine, Department of Medicine, University of Arizona, Tucson, Arizona; and.
Deborah A MeyersDivision of Genetics, Genomics, and Precision Medicine, Department of Medicine, University of Arizona, Tucson, Arizona; and.
Yi ZhaoDepartment of Biostatistics and Health Science Data, School of Medicine, Indiana University, Indianapolis, Indiana.
Sally E WenzelDepartment of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania.
Benjamin GastonDepartment of Pediatrics.
Cleveland Clinic · USPediatrics and Genetics · USBrigham and Women's Hospital · USCerner (United States) · USUniversity of Arizona · USUniversity of Kansas · USUniversity of Wisconsin–Madison · USWake Forest University · USCase Western Reserve University · USImperial College London · GBIndiana University Health · USPennsylvania State University · USThe University of Texas Medical Branch at Galveston · USUniversity of California, San Francisco · USUniversity of Pittsburgh · USUniversity of Virginia · US

Funding

Targeting pathological hyaluronan matricesP01HL103453 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI ERZURUM, SERPIL C. · 2011 to 2020
$26.8M
Tissue Processing and Cell Culture COreP01HL081064 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI ERZURUM, SERPIL C. · 2006 to 2019
$17.8M
Project 3 - Personalized cystic fibrosis treatment strategies with synergistic therapies Identified in vitro.P01HL128192 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI GASTON, BENJAMIN · 2016 to 2020
$12.2M
S-nitrosylation signaling in asthmaP01HL158507 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI LAHM, TIM · 2021 to 2025
$12.0M
S-nitrosothiol signaling in pulmonary epithelial cellsP01HL101871 · NHLBI · UNIVERSITY OF VIRGINIA · PI GASTON, BENJAMIN, LEWIS, STEPHEN JOHN · 2011 to 2015
$8.7M
Elucidating a novel molecular biomarker for castration-resistant prostate cancerR01CA172382 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI Nima Sharifi · 2012 to 2026
$5.2M
Redox Determinants of Severe AsthmaR01HL069170 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI ERZURUM, SERPIL C. · 2001 to 2010
$5.1M
Airway redox biochemistry as a deteriminant of asthma phenotype during adolescen*U10HL109250 · NHLBI · UNIVERSITY OF VIRGINIA · PI ERZURUM, SERPIL C., GASTON, BENJAMIN · 2011 to 2016
$4.2M
Compensatory steroidogenesis mechanisms in castration-resistant prostate cancerR01CA190289 · NCI · CLEVELAND CLINIC LERNER COM-CWRU · PI SHARIFI, NIMA · 2015 to 2019
$2.1M
Gender-based precision care for asthmaK08HL133381 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI ZEIN, JOE · 2017 to 2021
$836k
BLRD VA I01 BX002042NCI NIH HHS R01 CA172382NCI NIH HHS R01 CA190289NHLBI NIH HHS K08 HL133381NHLBI NIH HHS P01 HL081064NHLBI NIH HHS P01 HL101871NHLBI NIH HHS P01 HL103453NHLBI NIH HHS P01 HL128192NHLBI NIH HHS P01 HL158507NHLBI NIH HHS R01 HL069170NHLBI NIH HHS U10 HL109250
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AdolescentAdultAgedAged, 80 and overAsthmaBreath TestsBronchoscopyDehydroepiandrosterone SulfateFemaleForced Expiratory VolumeGene ExpressionHumansMaleMiddle AgedNitric OxideNitric Oxide Synthase Type IIDehydroepiandrosterone SulfateNitric OxideNitric Oxide Synthase Type IINOS2 protein, humanReceptors, AndrogenRNA, Messengerairflow obstructionairway inflammationandrogensasthma

Identifiers

PMID33779531
PMCPMC8513596
OpenAlexW3140662285

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.