ArticleChronic respiratory disease
Diagnostic accuracy of multichannel intraluminal impedance-pH monitoring for gastroesophageal reflux-induced chronic cough.
Article in Chronic respiratory disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 11 citations in OpenAlex.
- Predictive factors for neuromodulator response in patients with nonacid gastroesophageal reflux-induced chronic cough: a retrospective data analysis.Therapeutic advances in chronic disease · 2025Article
- How to diagnose GERC more effectively: reflections on post-reflux swallow-induced peristaltic wave index and mean nocturnal baseline impedance.BMC pulmonary medicine · 2024Article
- Pathogenesis and management of gastroesophageal reflux disease-associated cough: a narrative review.Journal of thoracic disease · 2023Review
- Predictive value of clinical features for anti-reflux therapy response in suspected gastroesophageal reflux-induced chronic cough.Journal of thoracic disease · 2023Article
- Improved diagnostic yield of symptom association probability involving only cough for gastroesophageal reflux-induced chronic cough.Journal of thoracic disease · 2023Article
- Efficacy of laparoscopic fundoplication in patients with chronic cough and gastro-oesophageal reflux.Esophagus : official journal of the Japan Esophageal Society · 2023Article
- Post-reflux swallow-induced peristaltic wave index: a new parameter for the identification of non-acid gastroesophageal reflux-related chronic cough.Therapeutic advances in respiratory diseaseArticle
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo elucidate the accuracy and advantages of Multichannel intraluminal impedance-pH monitoring (MII-pH) in diagnosing gastroesophageal reflux-induced chronic cough (GERC).
methodsThe patients with suspected GERC were recruited and underwent MII-pH, GERC was confirmed by subsequent anti-reflux treatment despite the findings of MII-pH. Its diagnostic accuracy in identifying GERC were evaluated by receiver operating characteristic (ROC) analysis and compared with that of 24-h esophageal pH monitoring.
resultsAmong 158 patients completing both MII-pH and anti-reflux therapy, GERC was diagnosed in 136 patients, including acid GERC in 96 patients (70.6%), non-acid GERC in 30 patients (22.0%), neither one of both GERC in 10 patients (7.4%). For the identification of GERC, MII-pH presented with the sensitivity of 92.6%, specificity of 63.6%, positive predictive value of 94.0%, negative predictive value of 58.3% and area under ROC curve of 0.863, which was totally superior to 24-h esophageal pH monitoring. As the essential criteria of MII-pH, esophageal acid exposure time and symptom associated probability had a limited diagnostic value when used alone, but improved greatly the diagnostic yield when used in combination, even with a suboptimal efficacy.
conclusionMII-pH is a more sensitive test for identifying GERC, but with a suboptimal diagnostic efficacy.
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