SynthesisJournal of cutaneous medicine and surgery2021
Drugs Associated With the Development of Palmoplantar Keratoderma: A Systematic Review.
Synthesis in Journal of cutaneous medicine and surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 7 citations in OpenAlex.
- Bosutinib-induced palmoplantar keratoderma treated with acitretin.JAAD case reports · 2026Article
- Real-world safety profile of bisoprolol: signal detection and demographic stratification using the FAERS database.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Palmoplantar Keratoderma: A Mechanism-Based Disease Classification.Clinical, cosmetic and investigational dermatology · 2026Article
- Palmoplantar Keratoderma in a Patient of Chronic Myeloid Leukemia on Dasatinib.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2024Article
- A Rare Case on Capecitabine Induced Acquired Palmoplantar Keratoderma.Clinical, cosmetic and investigational dermatology · 2023Article
- Onychomadesis and palmoplantar keratoderma associated with talquetamab therapy for relapsed and refractory multiple myeloma.JAAD case reports · 2023Article
- Nivolumab Induced Palmoplantar Keratoderma.Indian dermatology online journalArticle
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPalmoplantar keratoderma (PPK) are a heterogenous group of hereditary and acquired disorders that are characterized by excessive epidermal thickening of the palms and/or soles. PPK has been described as a rare adverse event for some medications. The aim of this systematic review was to summarize outcomes in PPK associated with various medications. This data will assist dermatologists and other healthcare providers treating patients with drug-induced PPK.
methodsEMBASE and MEDLINE databases were searched in accordance with PRISMA guidelines using the keyword "palmoplantar keratoderma." 40 studies met the inclusion criteria.
resultsA total of 247 patients (mean age: 57.0 years) were included in the analysis. Among patients whose sex was reported, 60.3% (
conclusionsPPK was most frequently associated with targeted kinase inhibitors, specifically BRAF, MEK1/2, and tyrosine kinase inhibitors.
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Registered trials
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