Evidence map›Paper›PMID 33778923›Full record

ArticleInternational archives of occupational and environmental health2021

The association of three DNA repair genes polymorphisms on the frequency of chromosomal alterations detected by fluorescence in situ hybridization.

Fábio Santiago, Rafaele Tavares Silvestre, Ubirani Barros Otero, Marianne Medeiros Tabalipa, Marilza de Moura Ribeiro-Carvalho, Luciano Rios Scherrer, Ahmed Al-Rikabi, Thomas Liehr, Gilda Alves, Maria Helena Ornellas

Erratum issuedOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International archives of occupational and environmental health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 2 pooled it
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 syntheses or guidelines pooled it, 2 citations in OpenAlex.

  1. Recent Advances in Biomonitoring of Gas Station Workers: A Systematic Review.Asian Pacific journal of cancer prevention : APJCP · 2024
    Pooled it
  2. Pooled it
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Fábio SantiagoLaboratory of Circulating Biomarkers, Department of Pathology, Faculty of Medical Sciences, Rio de Janeiro State University (UERJ), Avenida Professor Manuel de Abreu 444, 4° andar, Vila Isabel, Rio de Janeiro, 20551-030, Brazil.ORCID http://orcid.org/0000-0001-8223-932X
Rafaele Tavares SilvestreLaboratory of Circulating Biomarkers, Department of Pathology, Faculty of Medical Sciences, Rio de Janeiro State University (UERJ), Avenida Professor Manuel de Abreu 444, 4° andar, Vila Isabel, Rio de Janeiro, 20551-030, Brazil.ORCID http://orcid.org/0000-0003-2009-537X
Ubirani Barros OteroTechnical Area Environmental, Work and Cancer, Coordination of Prevention and Surveillance, National Cancer Institute José Alencar Gomes da Silva (INCA), Rio de Janeiro, Brazil.ORCID http://orcid.org/0000-0003-1464-2410
Marianne Medeiros TabalipaTechnical Area Environmental, Work and Cancer, Coordination of Prevention and Surveillance, National Cancer Institute José Alencar Gomes da Silva (INCA), Rio de Janeiro, Brazil.ORCID http://orcid.org/0000-0001-7787-0758
Marilza de Moura Ribeiro-CarvalhoLaboratory of Circulating Biomarkers, Department of Pathology, Faculty of Medical Sciences, Rio de Janeiro State University (UERJ), Avenida Professor Manuel de Abreu 444, 4° andar, Vila Isabel, Rio de Janeiro, 20551-030, Brazil.ORCID http://orcid.org/0000-0002-6068-5991
Luciano Rios ScherrerKennedy Faculties of Belo Horizonte, Minas Gerais, Brazil.ORCID http://orcid.org/0000-0001-9014-7396
Ahmed Al-RikabiJena University Hospital, Friedrich Schiller University, Institute of Human Genetics, Jena, Germany.ORCID http://orcid.org/0000-0003-4474-4493
Thomas LiehrJena University Hospital, Friedrich Schiller University, Institute of Human Genetics, Jena, Germany.ORCID https://orcid.org/0000-0003-1672-3054
Gilda AlvesLaboratory of Circulating Biomarkers, Department of Pathology, Faculty of Medical Sciences, Rio de Janeiro State University (UERJ), Avenida Professor Manuel de Abreu 444, 4° andar, Vila Isabel, Rio de Janeiro, 20551-030, Brazil. galvesbrown@gmail.com.ORCID http://orcid.org/0000-0003-2246-719X
Maria Helena OrnellasLaboratory of Circulating Biomarkers, Department of Pathology, Faculty of Medical Sciences, Rio de Janeiro State University (UERJ), Avenida Professor Manuel de Abreu 444, 4° andar, Vila Isabel, Rio de Janeiro, 20551-030, Brazil.ORCID http://orcid.org/0000-0002-2983-9593
Universidade do Estado do Rio de Janeiro · BRInstituto Nacional de Câncer - INCA · BRJena University Hospital · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeGas station workers (GSWs) are exposed to carcinogenic agents. The aim was to study the association of high somatic chromosome alterations (CAs) rates in the blood of GSWs and the polymorphisms of three genes playing a role in DNA double-strand break repair.

methodsThis is a cross-sectional study with 114 GSWs and 115 age-matched controls. Cytogenetic analyses, blood exams, medical interviews and genotypes for RAD51/G135C (rs1801320), ATM/P1054R (rs1800057) and CHEK2/T470C (rs17879961) genes were performed.

resultsThe CA rate in GSWs was 9.8 CAs/1000 metaphases, and 19.1% of the workers had > 10 CAs per 1000 metaphases (group two). GSWs had decreased levels of monocytes (P = 0.024) in their blood exams. The number of variant alleles of the RAD51/G135C polymorphism was higher in GSWs (P = 0.011) compared to the controls, and were associated with enhanced number of CAs per worker (P = 0.008). No allele variant was found for CHEK2/T470C in this study.

conclusionThe RAD51/G135C polymorphism appears to be related to genome instability in gas station workers. Increasing the knowledge of DNA repair gene variations involved in maintaining genomic stability in GSWs may be crucial for future cancer prevention.

Indexed as

Chromosome AberrationsGasolineOccupational ExposureAdultAtaxia Telangiectasia Mutated ProteinsBrazilCheckpoint Kinase 2Cross-Sectional StudiesDNA RepairFemaleGenotypeHumansIn Situ Hybridization, FluorescenceMaleMiddle AgedOil and Gas IndustryAtaxia Telangiectasia Mutated ProteinsATM protein, humanCheckpoint Kinase 2CHEK2 protein, humanGasolineRAD51 protein, humanRad51 RecombinaseATM/P1054RBenzeneChromosome aberrationGas station workerRAD51/G135C

Identifiers

PMID33778923
PMCPMC8384795
OpenAlexW3146290760

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.