Evidence map›Paper›PMID 33778913›Full record

ArticleDocumenta ophthalmologica. Advances in ophthalmology2021

Repeated measurements of ERGs and VEPs using chloral hydrate sedation and propofol anesthesia in young children.

Daphne L McCulloch, Pamela Garcia-Filion, Marla Matar, Carly Stewart, Mark S Borchert

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In one paragraph

Article in Documenta ophthalmologica. Advances in ophthalmology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Genetic testing for infantile nystagmus syndrome with or without associated findings.Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus · 2023
    Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Daphne L McCullochSchool of Optometry and Vision Sciences, University of Waterloo, Waterloo, ON, Canada. daphne.mcculloch@uwaterloo.ca.ORCID 0000-0003-3519-4207
Pamela Garcia-FilionDepartment of Ophthalmology, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Marla MatarKeck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Carly StewartDepartment of Ophthalmology, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Mark S BorchertDepartment of Ophthalmology, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Children's Hospital of Los Angeles · USUniversity of Southern California · USUniversity of Waterloo · CA

Funding

Southern California Clinical and Translational Science InstituteUL1TR000130 · NCATS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BUCHANAN, THOMAS A · 2012 to 2015
$36.0M
NCATS NIH HHS UL1 TR000130
6 · The paper itself

Abstract

purposeSedation with chloral hydrate or anesthesia using propofol allow ocular examination and testing in young children, but these drugs may affect electrophysiologic recordings. We compared the flash and pattern ERGs and VEPs recorded with each drug in a cohort of young children enrolled in a prospective study of optic nerve hypoplasia (ONH) syndrome.

methodsERGs and VEPs to light-adapted, standard, full-field flashes, to standard and steady-state pattern-reversal (PR) were recorded with cycloplegia in 9 participants. Age range at the first session, with chloral hydrate was 8-23 mo; at the second session with propofol it was 20-29 mo. Examiners masked to the drug and clinical conditions measured the waveforms for longitudinal, paired comparisons between the sessions.

resultsFlash ERG amplitudes did not differ between sessions; peak times were longer at the second session (propofol) by clinically insignificant amounts (< 2 ms, p = 0.002). Standard PERGs had larger amplitudes and later peaks in the second session (propofol) than with chloral hydrate (P50 2.9 vs 4.7 μV, p = 0.016 and 43 vs 52 ms, p < 0.001; N95 4.0 vs 6.1 μV, p = 0.003 and 91 vs 98.5 ms p = 0.034.). These differences were present for those with an interval of  > 10 mo between sessions (n = 5, 10 eyes) but not for those with a shorter inter-test interval (< 8 mo, p > 0.05, n = 4). Magnitudes of the steady-state PERGs did not differ between tests but the waveforms had earlier peaks at the second test with propofol. Flash VEP waveforms were present in 10/18 eyes and showed 72% agreement for recordability between sessions. Standard pattern VEPs were recordable in only a few eyes in this cohort with ONH.

conclusionsLight-adapted flash ERG waveforms were generally similar with chloral hydrate and with propofol. Larger PERGs with later peaks, found in the second session (propofol) could reflect maturation of the PERG generators, as the differences found were associated with a greater age difference between the sessions, but we do not rule out that small differences in the waveforms may be drug-related. There are insufficient VEP data from these children with ONH to identify drug-related or maturational effects on VEPs.

Indexed as

AnesthesiaElectroretinographyPropofolChildChild, PreschoolChloral HydrateHumansProspective StudiesChloral HydratePropofolAnesthesiaChildrenChloral hydrateClinical electrophysiology of visionElectroretinogram (ERG)Optic nerve hypoplasiaPattern ERG (PERG)PropofolSedationVisual Evoked Potential (VEP)

Identifiers

PMID33778913
OpenAlexW3149089422

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.