Evidence map›Paper›PMID 33778856›Full record

ArticleAmerican journal of epidemiology2021

Trends in "Deaths of Despair" Among Working-Aged White and Black Americans, 1990-2017.

Andrea M Tilstra, Daniel H Simon, Ryan K Masters

Open access · greenAbstract read
In one paragraph

Article in American journal of epidemiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
13.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. A Multivariate Genomic Investigation of the Externalizing Spectrum and Suicide Risk.medRxiv : the preprint server for health sciences · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Identifying the Changing Landscape of Younger Adult Mortality in the United States from 1999 to 2021.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2025
    Observational
  12. Article
  13. Observational
  14. Observational
  15. The Role of Despair in Predicting Self-Destructive Behaviors.Population research and policy review · 2025
    Article
  16. Article
  17. Article
  18. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Andrea M Tilstra
Daniel H Simon
Ryan K Masters

Funding

Network on Life Course Health Dynamics and Disparities in 21st Century America RenewalR24AG045061 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JENNIFER A AILSHIRE, Sarah A. Burgard · 2014 to 2026
$5.2M
University of Colorado Population CenterP2CHD066613 · NICHD · UNIVERSITY OF COLORADO · PI JANE A MENKEN · 2015 to 2026
$3.7M
NIA NIH HHS R24 AG045061NICHD NIH HHS P2C HD066613
6 · The paper itself

Abstract

Life expectancy for US White men and women declined between 2013 and 2017. Initial explanations for the decline focused on increases in "deaths of despair" (i.e., deaths from suicide, drug use, and alcohol use), which have been interpreted as a cohort-based phenomenon afflicting middle-aged White Americans. There has been less attention on Black mortality trends from these same causes, and whether the trends are similar or different by cohort and period. We complement existing research and contend that recent mortality trends in both the US Black and White populations most likely reflect period-based exposures to 1) the US opioid epidemic and 2) the Great Recession. We analyzed cause-specific mortality trends in the United States for deaths from suicide, drug use, and alcohol use among non-Hispanic Black and non-Hispanic White Americans, aged 20-64 years, over 1990-2017. We employed sex-, race-, and cause-of-death-stratified Poisson rate models and age-period-cohort models to compare mortality trends. Results indicate that rising "deaths of despair" for both Black and White Americans are overwhelmingly driven by period-based increases in drug-related deaths since the late 1990s. Further, deaths related to alcohol use and suicide among both White and Black Americans changed during the Great Recession, despite some racial differences across cohorts.

Indexed as

MortalityAdultAlcoholismBlack or African AmericanCause of DeathEconomic RecessionFemaleHumansMaleMiddle AgedSubstance-Related DisordersSuicideWhite PeopleYoung Adultage-period-cohort modelsdeaths of despairmidlife mortalitymortality trendsopioidracial/ethnic trendsUnited States

Identifiers

PMID33778856
PMCPMC8579049
OpenAlexW3142976211

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.