Evidence map›Paper›PMID 33778784›Full record

ArticleSTAR protocols2021

Alginate-based 3D cancer cell culture for therapeutic response modeling.

Farideh Davoudi, Samar Ghorbanpoor, Satoshi Yoda, Xiao Pan, Giovanna Stein Crowther, Xunqin Yin, Ellen Murchie, Aaron N Hata, Henning Willers, Cyril H Benes

Abstract read
In one paragraph

Article in STAR protocols, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Live Metabolomics with NMR.Analytical chemistry · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Screening and Validation of Molecular Targeted Radiosensitizers.International journal of radiation oncology, biology, physics · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Farideh DavoudiMassachusetts General Hospital, Center for Cancer Research, Harvard Medical School, 149 13th Street, Boston, MA 02129, USA.
Samar GhorbanpoorMassachusetts General Hospital, Center for Cancer Research, Harvard Medical School, 149 13th Street, Boston, MA 02129, USA.
Satoshi YodaMassachusetts General Hospital, Center for Cancer Research, Harvard Medical School, 149 13th Street, Boston, MA 02129, USA.
Xiao PanDepartment of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA.
Giovanna Stein CrowtherMassachusetts General Hospital, Center for Cancer Research, Harvard Medical School, 149 13th Street, Boston, MA 02129, USA.
Xunqin YinMassachusetts General Hospital, Center for Cancer Research, Harvard Medical School, 149 13th Street, Boston, MA 02129, USA.
Ellen MurchieMassachusetts General Hospital, Center for Cancer Research, Harvard Medical School, 149 13th Street, Boston, MA 02129, USA.
Aaron N HataMassachusetts General Hospital, Center for Cancer Research, Harvard Medical School, 149 13th Street, Boston, MA 02129, USA.
Henning WillersDepartment of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA.
Cyril H BenesMassachusetts General Hospital, Center for Cancer Research, Harvard Medical School, 149 13th Street, Boston, MA 02129, USA.

Funding

High-Throughput Screening and Validation of Molecular Targeted ChemoradiosensitizersU01CA220714 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI HATA, AARON N, WILLERS, HENNING · 2018 to 2022
$3.1M
NCI NIH HHS U01 CA220714
6 · The paper itself

Abstract

Two-dimensional (2D) culture of tumor cells fails to recapitulate some important aspects of cellular organization seen in

Indexed as

AlginatesAntineoplastic AgentsCalcium ChlorideCell Culture Techniques, Three DimensionalCell Line, TumorCell ProliferationCell SurvivalHumansModels, BiologicalAlginatesAntineoplastic AgentsCalcium ChlorideCancerCell-based assaysCell cultureHigh-throughput screening

Identifiers

PMID33778784
PMCPMC7985559

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.