Evidence map›Paper›PMID 33778734›Full record

ArticleRadiology. Imaging cancer2020

mTOR Inhibitor Therapy for Tuberous Sclerosis Complex: Longitudinal Study of Muscle Mass Determined by Abdominal Cross-sectional Imaging with CT and MRI.

Caroline Raab, Leah A Gilligan, Andrew T Trout, Darcy A Krueger, David N Franz, Bin Zhang, Alexander J Towbin

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiology. Imaging cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Caroline RaabDepartment of Pediatric Neurology, Diakonie Kork, Kehl, Germany (C.R.); Department of Radiology (L.A.G., A.T.T., A.J.T.), Division of Neurology (D.A.K., D.N.F.), and Division of Biostatistics and Epidemiology (B.Z.), Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, MLC 5031, Cincinnati, OH 45229; and Departments of Radiology (A.T.T., A.J.T.) and Pediatrics (D.A.K., D.N.F., B.Z.), University of Cincinnati College of Medicine, Cincinnati, Ohio.
Leah A GilliganDepartment of Pediatric Neurology, Diakonie Kork, Kehl, Germany (C.R.); Department of Radiology (L.A.G., A.T.T., A.J.T.), Division of Neurology (D.A.K., D.N.F.), and Division of Biostatistics and Epidemiology (B.Z.), Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, MLC 5031, Cincinnati, OH 45229; and Departments of Radiology (A.T.T., A.J.T.) and Pediatrics (D.A.K., D.N.F., B.Z.), University of Cincinnati College of Medicine, Cincinnati, Ohio.ORCID 0000-0002-4632-7004
Andrew T TroutDepartment of Pediatric Neurology, Diakonie Kork, Kehl, Germany (C.R.); Department of Radiology (L.A.G., A.T.T., A.J.T.), Division of Neurology (D.A.K., D.N.F.), and Division of Biostatistics and Epidemiology (B.Z.), Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, MLC 5031, Cincinnati, OH 45229; and Departments of Radiology (A.T.T., A.J.T.) and Pediatrics (D.A.K., D.N.F., B.Z.), University of Cincinnati College of Medicine, Cincinnati, Ohio.ORCID 0000-0003-1431-4054
Darcy A KruegerDepartment of Pediatric Neurology, Diakonie Kork, Kehl, Germany (C.R.); Department of Radiology (L.A.G., A.T.T., A.J.T.), Division of Neurology (D.A.K., D.N.F.), and Division of Biostatistics and Epidemiology (B.Z.), Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, MLC 5031, Cincinnati, OH 45229; and Departments of Radiology (A.T.T., A.J.T.) and Pediatrics (D.A.K., D.N.F., B.Z.), University of Cincinnati College of Medicine, Cincinnati, Ohio.
David N FranzDepartment of Pediatric Neurology, Diakonie Kork, Kehl, Germany (C.R.); Department of Radiology (L.A.G., A.T.T., A.J.T.), Division of Neurology (D.A.K., D.N.F.), and Division of Biostatistics and Epidemiology (B.Z.), Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, MLC 5031, Cincinnati, OH 45229; and Departments of Radiology (A.T.T., A.J.T.) and Pediatrics (D.A.K., D.N.F., B.Z.), University of Cincinnati College of Medicine, Cincinnati, Ohio.
Bin ZhangDepartment of Pediatric Neurology, Diakonie Kork, Kehl, Germany (C.R.); Department of Radiology (L.A.G., A.T.T., A.J.T.), Division of Neurology (D.A.K., D.N.F.), and Division of Biostatistics and Epidemiology (B.Z.), Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, MLC 5031, Cincinnati, OH 45229; and Departments of Radiology (A.T.T., A.J.T.) and Pediatrics (D.A.K., D.N.F., B.Z.), University of Cincinnati College of Medicine, Cincinnati, Ohio.ORCID 0000-0003-0607-1806
Alexander J TowbinDepartment of Pediatric Neurology, Diakonie Kork, Kehl, Germany (C.R.); Department of Radiology (L.A.G., A.T.T., A.J.T.), Division of Neurology (D.A.K., D.N.F.), and Division of Biostatistics and Epidemiology (B.Z.), Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, MLC 5031, Cincinnati, OH 45229; and Departments of Radiology (A.T.T., A.J.T.) and Pediatrics (D.A.K., D.N.F., B.Z.), University of Cincinnati College of Medicine, Cincinnati, Ohio.ORCID 0000-0003-1729-5071
Cincinnati Children's Hospital Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To determine the effect of chronic mammalian target of rapamycin (mTOR) inhibition on skeletal muscle mass in patients with tuberous sclerosis complex (TSC). Materials and Methods: In this retrospective study, patients with TSC who were taking mTOR inhibitors and who underwent at least two abdominal CT or MRI examinations between 2005 and 2017 were included ( Results: The 24 patients underwent a total of 129 abdominal CT or MRI examinations. Median duration of mTOR inhibition at last examination was 106 months (range, 1310-3717 days). There was no significant association between the duration of mTOR inhibitor therapy and psoas muscle area on multiple linear mixed-effect modeling ( Conclusion: Duration of mTOR inhibition in TSC was not significantly associated with a decrease in psoas muscle area, suggesting that chronic mTOR inhibition is not associated with sarcopenia.

Indexed as

Tuberous SclerosisAdolescentChildFemaleHumansLongitudinal StudiesMagnetic Resonance ImagingMalePsoas MusclesRetrospective StudiesTomography, X-Ray ComputedTOR Serine-Threonine KinasesMTOR protein, humanTOR Serine-Threonine Kinases

Identifiers

PMID33778734
PMCPMC7983794
OpenAlexW3087471417

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.