Evidence map›Paper›PMID 33778683›Full record

ArticleRadiology. Imaging cancer2019

Development of a Human Photoacoustic Imaging Reporter Gene Using the Clinical Dye Indocyanine Green.

Nivin N Nyström, Lawrence C M Yip, Jeffrey J L Carson, Timothy J Scholl, John A Ronald

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiology. Imaging cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
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  7. Visualizing cell-cell communication using synthetic notch activated MRI.Proceedings of the National Academy of Sciences of the United States of America · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nivin N NyströmDepartment of Medical Biophysics, University of Western Ontario, 1151 Richmond St N, Room 2241A, London, ON, Canada N6A 3K7 (N.N.N., L.C.M.Y., J.J.L.C., T.J.S., J.A.R.); Imaging Research Laboratories, Robarts Research Institute, London, Canada (N.N.N., T.J.S., J.A.R.); Lawson Health Research Institute, London, Canada (L.C.M.Y., J.J.L.C., J.A.R.); and Ontario Institute for Cancer Research, Toronto, Canada (T.J.S.).ORCID 0000-0001-6288-6060
Lawrence C M YipDepartment of Medical Biophysics, University of Western Ontario, 1151 Richmond St N, Room 2241A, London, ON, Canada N6A 3K7 (N.N.N., L.C.M.Y., J.J.L.C., T.J.S., J.A.R.); Imaging Research Laboratories, Robarts Research Institute, London, Canada (N.N.N., T.J.S., J.A.R.); Lawson Health Research Institute, London, Canada (L.C.M.Y., J.J.L.C., J.A.R.); and Ontario Institute for Cancer Research, Toronto, Canada (T.J.S.).ORCID 0000-0003-0014-8112
Jeffrey J L CarsonDepartment of Medical Biophysics, University of Western Ontario, 1151 Richmond St N, Room 2241A, London, ON, Canada N6A 3K7 (N.N.N., L.C.M.Y., J.J.L.C., T.J.S., J.A.R.); Imaging Research Laboratories, Robarts Research Institute, London, Canada (N.N.N., T.J.S., J.A.R.); Lawson Health Research Institute, London, Canada (L.C.M.Y., J.J.L.C., J.A.R.); and Ontario Institute for Cancer Research, Toronto, Canada (T.J.S.).
Timothy J SchollDepartment of Medical Biophysics, University of Western Ontario, 1151 Richmond St N, Room 2241A, London, ON, Canada N6A 3K7 (N.N.N., L.C.M.Y., J.J.L.C., T.J.S., J.A.R.); Imaging Research Laboratories, Robarts Research Institute, London, Canada (N.N.N., T.J.S., J.A.R.); Lawson Health Research Institute, London, Canada (L.C.M.Y., J.J.L.C., J.A.R.); and Ontario Institute for Cancer Research, Toronto, Canada (T.J.S.).ORCID 0000-0002-0807-363X
John A RonaldDepartment of Medical Biophysics, University of Western Ontario, 1151 Richmond St N, Room 2241A, London, ON, Canada N6A 3K7 (N.N.N., L.C.M.Y., J.J.L.C., T.J.S., J.A.R.); Imaging Research Laboratories, Robarts Research Institute, London, Canada (N.N.N., T.J.S., J.A.R.); Lawson Health Research Institute, London, Canada (L.C.M.Y., J.J.L.C., J.A.R.); and Ontario Institute for Cancer Research, Toronto, Canada (T.J.S.).ORCID 0000-0003-3665-173X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To develop a photoacoustic imaging (PAI) reporter gene that has high translational potential. Previous research has shown that human organic anion-transporting polypeptide 1b3 (OATP1B3) promotes the uptake of the near-infrared fluorescent dye indocyanine green (ICG). In this study, the authors have established Materials and Methods: Human breast cancer cells were engineered to express Results: Conclusion:

Indexed as

Genes, ReporterAnalysis of VarianceAnimalsBreast NeoplasmsCell EngineeringCell Line, TumorColoring AgentsFemaleHumansIndocyanine GreenMiceOptical ImagingPhotoacoustic TechniquesSolute Carrier Organic Anion Transporter Family Member 1B3Coloring AgentsIndocyanine GreenSolute Carrier Organic Anion Transporter Family Member 1B3

Identifiers

PMID33778683
PMCPMC7983684

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.