Evidence map›Paper›PMID 33778639›Full record

ArticleRadiology. Cardiothoracic imaging2020

Ferumoxytol-enhanced MR Venography of the Central Veins of the Thorax for the Evaluation of Stenosis and Occlusion in Patients with Renal Impairment.

Christopher J R Gallo, Joseph G Mammarappallil, David Y Johnson, Hamid Chalian, James Ronald, Mustafa R Bashir, Charles Y Kim

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiology. Cardiothoracic imaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07452250 (A Single-center, Evaluator-blinded Clinical Study of Polysaccharide Superparamagnetic Iron Oxide Injection for Magnetic Resonance Venography in Patients With Venous System Diseases), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07452250 phase2recruitingnot on this mapstarted 2026, after this paper: background citation

A Single-center, Evaluator-blinded Clinical Study of Polysaccharide Superparamagnetic Iron Oxide Injection for Magnetic Resonance Venography in Patients With Venous System Diseases

TypeinterventionalSponsorMin ZhouRan2026 to 2026Enrolled50ConditionsVenous DiseasesArmsFerumoxytol injection
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Christopher J R GalloDivision of Vascular and Interventional Radiology (C.J.R.G., D.Y.J., J.R., C.Y.K.), Division of Cardiothoracic Imaging (J.G.M., D.Y.J., H.C.), Division of Abdominal Imaging, Department of Radiology (M.R.B.), Center for Advanced Magnetic Resonance Development (M.R.B.), and Division of Hepatology, Department of Medicine (M.R.B.), Duke University Medical Center, Box 3808, 2301 Erwin Rd, Durham, NC 27710.ORCID 0000-0003-2928-8047
Joseph G MammarappallilDivision of Vascular and Interventional Radiology (C.J.R.G., D.Y.J., J.R., C.Y.K.), Division of Cardiothoracic Imaging (J.G.M., D.Y.J., H.C.), Division of Abdominal Imaging, Department of Radiology (M.R.B.), Center for Advanced Magnetic Resonance Development (M.R.B.), and Division of Hepatology, Department of Medicine (M.R.B.), Duke University Medical Center, Box 3808, 2301 Erwin Rd, Durham, NC 27710.
David Y JohnsonDivision of Vascular and Interventional Radiology (C.J.R.G., D.Y.J., J.R., C.Y.K.), Division of Cardiothoracic Imaging (J.G.M., D.Y.J., H.C.), Division of Abdominal Imaging, Department of Radiology (M.R.B.), Center for Advanced Magnetic Resonance Development (M.R.B.), and Division of Hepatology, Department of Medicine (M.R.B.), Duke University Medical Center, Box 3808, 2301 Erwin Rd, Durham, NC 27710.ORCID 0000-0002-8846-2757
Hamid ChalianDivision of Vascular and Interventional Radiology (C.J.R.G., D.Y.J., J.R., C.Y.K.), Division of Cardiothoracic Imaging (J.G.M., D.Y.J., H.C.), Division of Abdominal Imaging, Department of Radiology (M.R.B.), Center for Advanced Magnetic Resonance Development (M.R.B.), and Division of Hepatology, Department of Medicine (M.R.B.), Duke University Medical Center, Box 3808, 2301 Erwin Rd, Durham, NC 27710.ORCID 0000-0001-8357-7347
James RonaldDivision of Vascular and Interventional Radiology (C.J.R.G., D.Y.J., J.R., C.Y.K.), Division of Cardiothoracic Imaging (J.G.M., D.Y.J., H.C.), Division of Abdominal Imaging, Department of Radiology (M.R.B.), Center for Advanced Magnetic Resonance Development (M.R.B.), and Division of Hepatology, Department of Medicine (M.R.B.), Duke University Medical Center, Box 3808, 2301 Erwin Rd, Durham, NC 27710.ORCID 0000-0002-2959-4354
Mustafa R BashirDivision of Vascular and Interventional Radiology (C.J.R.G., D.Y.J., J.R., C.Y.K.), Division of Cardiothoracic Imaging (J.G.M., D.Y.J., H.C.), Division of Abdominal Imaging, Department of Radiology (M.R.B.), Center for Advanced Magnetic Resonance Development (M.R.B.), and Division of Hepatology, Department of Medicine (M.R.B.), Duke University Medical Center, Box 3808, 2301 Erwin Rd, Durham, NC 27710.ORCID 0000-0001-8800-5057
Charles Y KimDivision of Vascular and Interventional Radiology (C.J.R.G., D.Y.J., J.R., C.Y.K.), Division of Cardiothoracic Imaging (J.G.M., D.Y.J., H.C.), Division of Abdominal Imaging, Department of Radiology (M.R.B.), Center for Advanced Magnetic Resonance Development (M.R.B.), and Division of Hepatology, Department of Medicine (M.R.B.), Duke University Medical Center, Box 3808, 2301 Erwin Rd, Durham, NC 27710.
Duke University · USDuke Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo assess the diagnostic performance of ferumoxytol-enhanced MR venography for the detection of thoracic central vein stenosis or occlusion with conventional venography as the reference standard. MATERIALS AND

methodsIn this retrospective study, consecutive patients from May 2012 to December 2018 underwent dedicated ferumoxytol-enhanced MR venography of the thoracic central veins and conventional venography within 6 months for detecting central venous stenosis. The central veins were divided into seven segments for evaluation. MR venography images were evaluated by three radiologists for presence of stenosis or occlusion. Interobserver agreement was assessed using Fleiss κ.

resultsA total of 35 patients were included (mean age, 49 years; age range, 12-75 years; 18 females). Of the 122 total venous segments with corresponding conventional venography, 73 were stenotic or occluded. The sensitivity and specificity for detection of stenosis or occlusion was 99% and 98%, respectively. The sensitivity and specificity for detecting occlusion alone was 96% and 98%, respectively. MR venography readers demonstrated moderate agreement in their ability to grade stenosis or occlusion (κ = 0.59). There were no adverse events related to contrast agent administration.

conclusionFerumoxytol-enhanced MR venography demonstrated excellent sensitivity and specificity for detection of thoracic central vein stenosis or occlusion.© RSNA, 2020See also the commentary by Finn in this issue.

Identifiers

PMID33778639
PMCPMC7977948
OpenAlexW3105182969

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.