Evidence map›Paper›PMID 33778551›Full record

ArticleRadiology. Cardiothoracic imaging2020

Variability of MRI Aortic Stiffness Measurements in a Multicenter Clinical Trial Setting: Intraobserver, Interobserver, and Intracenter Variability of Pulse Wave Velocity and Aortic Strain Measurement.

Maja Hrabak-Paar, Achim Kircher, Saeed Al Sayari, Sebastien Kopp, Francesco Santini, Roland E Schmieder, Nadjia Kachenoura, Denise Yates, Thomas Langenickel, Jens Bremerich and 1 more

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiology. Cardiothoracic imaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01870739 (A Randomized, Double-blind, Active-controlled, Parallel Group, 52-week Study to Evaluate the Effect of LCZ696 Compared to Olmesartan on Regional Aortic Stiffness in Subjects With Essential Hypertension), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01870739 phase2completednot on this map

A Randomized, Double-blind, Active-controlled, Parallel Group, 52-week Study to Evaluate the Effect of LCZ696 Compared to Olmesartan on Regional Aortic Stiffness in Subjects With Essential Hypertension

TypeinterventionalSponsorNovartis PharmaceuticalsRan2013 to 2015Enrolled115ConditionsHypertensionArmssacubitril/valsartan (LCZ696), olmesartan, placebo to sacubitril/valsartan (LCZ696), placebo to olmesartan, Amlodipine (Optional)
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 5 countries.

Maja Hrabak-PaarClinic of Radiology and Nuclear Medicine, University of Basel Hospital, Basel, Switzerland (M.H.P., S.K., F.S., J.B., T.H.); Department of Diagnostic and Interventional Radiology, University Hospital Center Zagreb, University of Zagreb School of Medicine, Kispaticeva 12, HR-10000 Zagreb, Croatia (M.H.P.); Radiologie-Team Ortenau, Lahr, Germany (A.K.); Shaikh Khalifa Medical City, Abu Dhabi, United Arab Emirates (S.A.S.); Department of Biomedical Engineering, University of Basel, Switzerland (F.S.); Department of Nephrology and Hypertension, University Hospital Erlangen, Germany (R.E.S.); Cardiovascular Imaging Department, European Hospital Georges Pompidou, University of Paris, France (N.K.); and Novartis Institutes for Biomedical Research, Cambridge, Mass (D.Y., T.L.).ORCID 0000-0002-0390-8466
Achim KircherClinic of Radiology and Nuclear Medicine, University of Basel Hospital, Basel, Switzerland (M.H.P., S.K., F.S., J.B., T.H.); Department of Diagnostic and Interventional Radiology, University Hospital Center Zagreb, University of Zagreb School of Medicine, Kispaticeva 12, HR-10000 Zagreb, Croatia (M.H.P.); Radiologie-Team Ortenau, Lahr, Germany (A.K.); Shaikh Khalifa Medical City, Abu Dhabi, United Arab Emirates (S.A.S.); Department of Biomedical Engineering, University of Basel, Switzerland (F.S.); Department of Nephrology and Hypertension, University Hospital Erlangen, Germany (R.E.S.); Cardiovascular Imaging Department, European Hospital Georges Pompidou, University of Paris, France (N.K.); and Novartis Institutes for Biomedical Research, Cambridge, Mass (D.Y., T.L.).
Saeed Al SayariClinic of Radiology and Nuclear Medicine, University of Basel Hospital, Basel, Switzerland (M.H.P., S.K., F.S., J.B., T.H.); Department of Diagnostic and Interventional Radiology, University Hospital Center Zagreb, University of Zagreb School of Medicine, Kispaticeva 12, HR-10000 Zagreb, Croatia (M.H.P.); Radiologie-Team Ortenau, Lahr, Germany (A.K.); Shaikh Khalifa Medical City, Abu Dhabi, United Arab Emirates (S.A.S.); Department of Biomedical Engineering, University of Basel, Switzerland (F.S.); Department of Nephrology and Hypertension, University Hospital Erlangen, Germany (R.E.S.); Cardiovascular Imaging Department, European Hospital Georges Pompidou, University of Paris, France (N.K.); and Novartis Institutes for Biomedical Research, Cambridge, Mass (D.Y., T.L.).ORCID 0000-0002-2182-6990
Sebastien KoppClinic of Radiology and Nuclear Medicine, University of Basel Hospital, Basel, Switzerland (M.H.P., S.K., F.S., J.B., T.H.); Department of Diagnostic and Interventional Radiology, University Hospital Center Zagreb, University of Zagreb School of Medicine, Kispaticeva 12, HR-10000 Zagreb, Croatia (M.H.P.); Radiologie-Team Ortenau, Lahr, Germany (A.K.); Shaikh Khalifa Medical City, Abu Dhabi, United Arab Emirates (S.A.S.); Department of Biomedical Engineering, University of Basel, Switzerland (F.S.); Department of Nephrology and Hypertension, University Hospital Erlangen, Germany (R.E.S.); Cardiovascular Imaging Department, European Hospital Georges Pompidou, University of Paris, France (N.K.); and Novartis Institutes for Biomedical Research, Cambridge, Mass (D.Y., T.L.).
Francesco SantiniClinic of Radiology and Nuclear Medicine, University of Basel Hospital, Basel, Switzerland (M.H.P., S.K., F.S., J.B., T.H.); Department of Diagnostic and Interventional Radiology, University Hospital Center Zagreb, University of Zagreb School of Medicine, Kispaticeva 12, HR-10000 Zagreb, Croatia (M.H.P.); Radiologie-Team Ortenau, Lahr, Germany (A.K.); Shaikh Khalifa Medical City, Abu Dhabi, United Arab Emirates (S.A.S.); Department of Biomedical Engineering, University of Basel, Switzerland (F.S.); Department of Nephrology and Hypertension, University Hospital Erlangen, Germany (R.E.S.); Cardiovascular Imaging Department, European Hospital Georges Pompidou, University of Paris, France (N.K.); and Novartis Institutes for Biomedical Research, Cambridge, Mass (D.Y., T.L.).ORCID 0000-0001-6984-4816
Roland E SchmiederClinic of Radiology and Nuclear Medicine, University of Basel Hospital, Basel, Switzerland (M.H.P., S.K., F.S., J.B., T.H.); Department of Diagnostic and Interventional Radiology, University Hospital Center Zagreb, University of Zagreb School of Medicine, Kispaticeva 12, HR-10000 Zagreb, Croatia (M.H.P.); Radiologie-Team Ortenau, Lahr, Germany (A.K.); Shaikh Khalifa Medical City, Abu Dhabi, United Arab Emirates (S.A.S.); Department of Biomedical Engineering, University of Basel, Switzerland (F.S.); Department of Nephrology and Hypertension, University Hospital Erlangen, Germany (R.E.S.); Cardiovascular Imaging Department, European Hospital Georges Pompidou, University of Paris, France (N.K.); and Novartis Institutes for Biomedical Research, Cambridge, Mass (D.Y., T.L.).
Nadjia KachenouraClinic of Radiology and Nuclear Medicine, University of Basel Hospital, Basel, Switzerland (M.H.P., S.K., F.S., J.B., T.H.); Department of Diagnostic and Interventional Radiology, University Hospital Center Zagreb, University of Zagreb School of Medicine, Kispaticeva 12, HR-10000 Zagreb, Croatia (M.H.P.); Radiologie-Team Ortenau, Lahr, Germany (A.K.); Shaikh Khalifa Medical City, Abu Dhabi, United Arab Emirates (S.A.S.); Department of Biomedical Engineering, University of Basel, Switzerland (F.S.); Department of Nephrology and Hypertension, University Hospital Erlangen, Germany (R.E.S.); Cardiovascular Imaging Department, European Hospital Georges Pompidou, University of Paris, France (N.K.); and Novartis Institutes for Biomedical Research, Cambridge, Mass (D.Y., T.L.).ORCID 0000-0002-5269-3246
Denise YatesClinic of Radiology and Nuclear Medicine, University of Basel Hospital, Basel, Switzerland (M.H.P., S.K., F.S., J.B., T.H.); Department of Diagnostic and Interventional Radiology, University Hospital Center Zagreb, University of Zagreb School of Medicine, Kispaticeva 12, HR-10000 Zagreb, Croatia (M.H.P.); Radiologie-Team Ortenau, Lahr, Germany (A.K.); Shaikh Khalifa Medical City, Abu Dhabi, United Arab Emirates (S.A.S.); Department of Biomedical Engineering, University of Basel, Switzerland (F.S.); Department of Nephrology and Hypertension, University Hospital Erlangen, Germany (R.E.S.); Cardiovascular Imaging Department, European Hospital Georges Pompidou, University of Paris, France (N.K.); and Novartis Institutes for Biomedical Research, Cambridge, Mass (D.Y., T.L.).ORCID 0000-0003-1039-515X
Thomas LangenickelClinic of Radiology and Nuclear Medicine, University of Basel Hospital, Basel, Switzerland (M.H.P., S.K., F.S., J.B., T.H.); Department of Diagnostic and Interventional Radiology, University Hospital Center Zagreb, University of Zagreb School of Medicine, Kispaticeva 12, HR-10000 Zagreb, Croatia (M.H.P.); Radiologie-Team Ortenau, Lahr, Germany (A.K.); Shaikh Khalifa Medical City, Abu Dhabi, United Arab Emirates (S.A.S.); Department of Biomedical Engineering, University of Basel, Switzerland (F.S.); Department of Nephrology and Hypertension, University Hospital Erlangen, Germany (R.E.S.); Cardiovascular Imaging Department, European Hospital Georges Pompidou, University of Paris, France (N.K.); and Novartis Institutes for Biomedical Research, Cambridge, Mass (D.Y., T.L.).
Jens BremerichClinic of Radiology and Nuclear Medicine, University of Basel Hospital, Basel, Switzerland (M.H.P., S.K., F.S., J.B., T.H.); Department of Diagnostic and Interventional Radiology, University Hospital Center Zagreb, University of Zagreb School of Medicine, Kispaticeva 12, HR-10000 Zagreb, Croatia (M.H.P.); Radiologie-Team Ortenau, Lahr, Germany (A.K.); Shaikh Khalifa Medical City, Abu Dhabi, United Arab Emirates (S.A.S.); Department of Biomedical Engineering, University of Basel, Switzerland (F.S.); Department of Nephrology and Hypertension, University Hospital Erlangen, Germany (R.E.S.); Cardiovascular Imaging Department, European Hospital Georges Pompidou, University of Paris, France (N.K.); and Novartis Institutes for Biomedical Research, Cambridge, Mass (D.Y., T.L.).
Tobias HeyeClinic of Radiology and Nuclear Medicine, University of Basel Hospital, Basel, Switzerland (M.H.P., S.K., F.S., J.B., T.H.); Department of Diagnostic and Interventional Radiology, University Hospital Center Zagreb, University of Zagreb School of Medicine, Kispaticeva 12, HR-10000 Zagreb, Croatia (M.H.P.); Radiologie-Team Ortenau, Lahr, Germany (A.K.); Shaikh Khalifa Medical City, Abu Dhabi, United Arab Emirates (S.A.S.); Department of Biomedical Engineering, University of Basel, Switzerland (F.S.); Department of Nephrology and Hypertension, University Hospital Erlangen, Germany (R.E.S.); Cardiovascular Imaging Department, European Hospital Georges Pompidou, University of Paris, France (N.K.); and Novartis Institutes for Biomedical Research, Cambridge, Mass (D.Y., T.L.).
University Hospital Centre Zagreb · HRNovartis (Switzerland) · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo assess intraobserver, interobserver, and scan-rescan variability of MRI aortic stiffness measurements in a multicenter trial setting. MATERIALS AND

methodsThis study was a retrospective analysis of prospectively collected data in a multicenter prospective clinical trial (clinicaltrials.gov ID NCT01870739). Forty-five adult patients (31 men; mean age, 58 years ± 12 [standard deviation]; 15 patients per center; three centers) with arterial hypertension underwent standardized 3-T baseline MRI assessments between June and September 2014. Aortic strain was calculated from maximum and minimum aortic area measurements repeated three times by three readers at three aortic levels on three retrospectively gated axial gradient-echo (GRE) data sets. Pulse wave velocity (PWV) was assessed three times by five readers as Δx/Δt: Δx was measured on a parasagittal GRE image of the aortic arch, and Δt was extracted from ascending and descending aortic velocity curves created on three axial phase-contrast acquisitions. Intraobserver, interobserver, and scan-rescan variability was calculated using percentage coefficient of variation (COV).

resultsAortic strain variability was lowest at the level of the distal descending aorta (DDA) with median COVs of 1.6% for intraobserver variability, 4.0% for interobserver variability, and 10.3% for scan-rescan variability. It was highest at the ascending aorta (AA) with COVs of 3.6% for intraobserver variability, 10.7% for interobserver variability, and 19.8% for scan-rescan variability. Variability of PWV was low: 0.7% for intraobserver variability, 1.5% for interobserver variability, and 8.1% for scan-rescan variability.

conclusionLow variability can be achieved for aortic strain and PWV measurements in a multicenter trial setting using standardized MRI protocols. Although COV was lower when measuring aortic strain at DDA compared with AA, variability was acceptable at both anatomic locations.

Identifiers

PMID33778551
PMCPMC7978027
OpenAlexW3023728128

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Registered trials

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