Evidence map›Paper›PMID 33778519›Full record

ArticleRadiology. Cardiothoracic imaging2019

Diagnostic Performance of On-Site Coronary CT Angiography-derived Fractional Flow Reserve Based on Patient-specific Lumped Parameter Models.

Robbert W van Hamersvelt, Michiel Voskuil, Pim A de Jong, Martin J Willemink, Ivana Išgum, Tim Leiner

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiology. Cardiothoracic imaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Diagnostic accuracy of on-site coronary computed tomography-derived fractional flow reserve in the diagnosis of stable coronary artery disease.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2022
    Article
  7. Review
  8. Review
  9. Fractional Flow Reserve: Patient Selection and Perspectives.Vascular health and risk management · 2021
    Review
  10. Review
  11. Computed tomographic evaluation of myocardial ischemia.Japanese journal of radiology · 2020
    Review
  12. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Robbert W van HamersveltDepartments of Radiology (R.W.v.H., P.A.d.J., M.J.W., T.L.) and Cardiology (M.V.), University Medical Center Utrecht, Utrecht University, PO Box 85500, 3508GA Utrecht, the Netherlands; Department of Radiology, Stanford University School of Medicine, Stanford, Calif (M.J.W.); and Image Sciences Institute, University Medical Center Utrecht, Utrecht, the Netherlands (I.I.).ORCID 0000-0002-6084-0656
Michiel VoskuilDepartments of Radiology (R.W.v.H., P.A.d.J., M.J.W., T.L.) and Cardiology (M.V.), University Medical Center Utrecht, Utrecht University, PO Box 85500, 3508GA Utrecht, the Netherlands; Department of Radiology, Stanford University School of Medicine, Stanford, Calif (M.J.W.); and Image Sciences Institute, University Medical Center Utrecht, Utrecht, the Netherlands (I.I.).
Pim A de JongDepartments of Radiology (R.W.v.H., P.A.d.J., M.J.W., T.L.) and Cardiology (M.V.), University Medical Center Utrecht, Utrecht University, PO Box 85500, 3508GA Utrecht, the Netherlands; Department of Radiology, Stanford University School of Medicine, Stanford, Calif (M.J.W.); and Image Sciences Institute, University Medical Center Utrecht, Utrecht, the Netherlands (I.I.).ORCID 0000-0003-4840-6854
Martin J WilleminkDepartments of Radiology (R.W.v.H., P.A.d.J., M.J.W., T.L.) and Cardiology (M.V.), University Medical Center Utrecht, Utrecht University, PO Box 85500, 3508GA Utrecht, the Netherlands; Department of Radiology, Stanford University School of Medicine, Stanford, Calif (M.J.W.); and Image Sciences Institute, University Medical Center Utrecht, Utrecht, the Netherlands (I.I.).ORCID 0000-0002-6991-6557
Ivana IšgumDepartments of Radiology (R.W.v.H., P.A.d.J., M.J.W., T.L.) and Cardiology (M.V.), University Medical Center Utrecht, Utrecht University, PO Box 85500, 3508GA Utrecht, the Netherlands; Department of Radiology, Stanford University School of Medicine, Stanford, Calif (M.J.W.); and Image Sciences Institute, University Medical Center Utrecht, Utrecht, the Netherlands (I.I.).
Tim LeinerDepartments of Radiology (R.W.v.H., P.A.d.J., M.J.W., T.L.) and Cardiology (M.V.), University Medical Center Utrecht, Utrecht University, PO Box 85500, 3508GA Utrecht, the Netherlands; Department of Radiology, Stanford University School of Medicine, Stanford, Calif (M.J.W.); and Image Sciences Institute, University Medical Center Utrecht, Utrecht, the Netherlands (I.I.).ORCID 0000-0003-1885-5499
Utrecht University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the diagnostic performance of a prototype on-site coronary CT angiography-derived fractional flow reserve (CT FFR) algorithm, based on patient-specific lumped parameter models, for the detection of functionally significant stenosis defined by invasive FFR, and to compare the performance to anatomic evaluation of stenosis degree. MATERIALS AND

methodsIn this retrospective feasibility study, 77 vessels in 57 patients (42 of 57 [74%]) men; mean age, 58.5 years ± 9.2 [standard deviation]) who underwent clinically indicated coronary CT angiography within 60 days prior to an invasive FFR measurement were analyzed. Invasive FFR less than or equal to 0.80 was used to indicate a functionally significant stenosis. Diagnostic performance of CT FFR was evaluated and compared with evaluation of stenosis degree. Analysis was performed on a per-vessel basis.

resultsInvasive FFR revealed functionally significant stenoses in 37 vessels (48%). CT FFR showed a significantly increased ability to indicate functionally significant stenosis (area under the receiver operating characteristic curve [AUC], 0.87) compared with degree of stenosis at coronary CT angiography (AUC, 0.70; ΔAUC 0.17;

conclusionDiagnostic performance of on-site CT FFR was superior to stenosis evaluation at coronary CT angiography for identification of functionally significant coronary artery stenosis in patients suspected of having or known to have coronary artery disease.© RSNA, 2019See also commentary by Schoepf et al.

Identifiers

PMID33778519
PMCPMC7977806
OpenAlexW2983069991

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.