Evidence map›Paper›PMID 33778518›Full record

ArticleRadiology. Cardiothoracic imaging2019

Global Longitudinal Strain Analysis Using Cardiac MRI in Aortic Stenosis: Comparison with Left Ventricular Remodeling, Myocardial Fibrosis, and 2-year Clinical Outcomes.

Nicholas B Spath, Miquel Gomez, Russell J Everett, Scott Semple, Calvin W L Chin, Audrey C White, Alan G Japp, David E Newby, Marc R Dweck

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiology. Cardiothoracic imaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Nicholas B SpathBHF/University Centre for Cardiovascular Science, University of Edinburgh, Chancellor's Building, 47 Little France Crescent, Edinburgh EH16 4SB, Scotland (N.B.S., R.J.E., S.S., A.C.W., A.G.J., D.E.N., M.R.D.); Hospital del Mar Medical Research Institute, Universitat Autònoma de Barcelona, Barcelona, Spain (M.G.); Department of Cardiovascular Science, National Heart Center, Singapore (C.W.L.C.); and Department of Cardiology, Royal Infirmary of Edinburgh, Edinburgh, Scotland (A.G.J., D.E.N., M.R.D.).ORCID 0000-0001-9623-0158
Miquel GomezBHF/University Centre for Cardiovascular Science, University of Edinburgh, Chancellor's Building, 47 Little France Crescent, Edinburgh EH16 4SB, Scotland (N.B.S., R.J.E., S.S., A.C.W., A.G.J., D.E.N., M.R.D.); Hospital del Mar Medical Research Institute, Universitat Autònoma de Barcelona, Barcelona, Spain (M.G.); Department of Cardiovascular Science, National Heart Center, Singapore (C.W.L.C.); and Department of Cardiology, Royal Infirmary of Edinburgh, Edinburgh, Scotland (A.G.J., D.E.N., M.R.D.).
Russell J EverettBHF/University Centre for Cardiovascular Science, University of Edinburgh, Chancellor's Building, 47 Little France Crescent, Edinburgh EH16 4SB, Scotland (N.B.S., R.J.E., S.S., A.C.W., A.G.J., D.E.N., M.R.D.); Hospital del Mar Medical Research Institute, Universitat Autònoma de Barcelona, Barcelona, Spain (M.G.); Department of Cardiovascular Science, National Heart Center, Singapore (C.W.L.C.); and Department of Cardiology, Royal Infirmary of Edinburgh, Edinburgh, Scotland (A.G.J., D.E.N., M.R.D.).
Scott SempleBHF/University Centre for Cardiovascular Science, University of Edinburgh, Chancellor's Building, 47 Little France Crescent, Edinburgh EH16 4SB, Scotland (N.B.S., R.J.E., S.S., A.C.W., A.G.J., D.E.N., M.R.D.); Hospital del Mar Medical Research Institute, Universitat Autònoma de Barcelona, Barcelona, Spain (M.G.); Department of Cardiovascular Science, National Heart Center, Singapore (C.W.L.C.); and Department of Cardiology, Royal Infirmary of Edinburgh, Edinburgh, Scotland (A.G.J., D.E.N., M.R.D.).ORCID 0000-0002-4008-7564
Calvin W L ChinBHF/University Centre for Cardiovascular Science, University of Edinburgh, Chancellor's Building, 47 Little France Crescent, Edinburgh EH16 4SB, Scotland (N.B.S., R.J.E., S.S., A.C.W., A.G.J., D.E.N., M.R.D.); Hospital del Mar Medical Research Institute, Universitat Autònoma de Barcelona, Barcelona, Spain (M.G.); Department of Cardiovascular Science, National Heart Center, Singapore (C.W.L.C.); and Department of Cardiology, Royal Infirmary of Edinburgh, Edinburgh, Scotland (A.G.J., D.E.N., M.R.D.).ORCID 0000-0002-9867-4390
Audrey C WhiteBHF/University Centre for Cardiovascular Science, University of Edinburgh, Chancellor's Building, 47 Little France Crescent, Edinburgh EH16 4SB, Scotland (N.B.S., R.J.E., S.S., A.C.W., A.G.J., D.E.N., M.R.D.); Hospital del Mar Medical Research Institute, Universitat Autònoma de Barcelona, Barcelona, Spain (M.G.); Department of Cardiovascular Science, National Heart Center, Singapore (C.W.L.C.); and Department of Cardiology, Royal Infirmary of Edinburgh, Edinburgh, Scotland (A.G.J., D.E.N., M.R.D.).
Alan G JappBHF/University Centre for Cardiovascular Science, University of Edinburgh, Chancellor's Building, 47 Little France Crescent, Edinburgh EH16 4SB, Scotland (N.B.S., R.J.E., S.S., A.C.W., A.G.J., D.E.N., M.R.D.); Hospital del Mar Medical Research Institute, Universitat Autònoma de Barcelona, Barcelona, Spain (M.G.); Department of Cardiovascular Science, National Heart Center, Singapore (C.W.L.C.); and Department of Cardiology, Royal Infirmary of Edinburgh, Edinburgh, Scotland (A.G.J., D.E.N., M.R.D.).
David E NewbyBHF/University Centre for Cardiovascular Science, University of Edinburgh, Chancellor's Building, 47 Little France Crescent, Edinburgh EH16 4SB, Scotland (N.B.S., R.J.E., S.S., A.C.W., A.G.J., D.E.N., M.R.D.); Hospital del Mar Medical Research Institute, Universitat Autònoma de Barcelona, Barcelona, Spain (M.G.); Department of Cardiovascular Science, National Heart Center, Singapore (C.W.L.C.); and Department of Cardiology, Royal Infirmary of Edinburgh, Edinburgh, Scotland (A.G.J., D.E.N., M.R.D.).
Marc R DweckBHF/University Centre for Cardiovascular Science, University of Edinburgh, Chancellor's Building, 47 Little France Crescent, Edinburgh EH16 4SB, Scotland (N.B.S., R.J.E., S.S., A.C.W., A.G.J., D.E.N., M.R.D.); Hospital del Mar Medical Research Institute, Universitat Autònoma de Barcelona, Barcelona, Spain (M.G.); Department of Cardiovascular Science, National Heart Center, Singapore (C.W.L.C.); and Department of Cardiology, Royal Infirmary of Edinburgh, Edinburgh, Scotland (A.G.J., D.E.N., M.R.D.).
The Queen's Medical Research Institute · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo use global longitudinal strain (GLS) as a marker of left ventricular decompensation in aortic stenosis and to investigate the relationship of GLS measured with cardiac MRI with markers of myocardial fibrosis, symptom development, remodeling, and clinical outcomes. MATERIALS AND

methodsPatients with aortic stenosis and healthy control subjects were assessed. GLS was assessed by using cardiac MRI feature tracking, diffuse fibrosis by T1 mapping, and replacement fibrosis using late gadolinium enhancement. Follow-up was prospective for the primary endpoint of all-cause mortality.

resultsGLS was reduced in aortic stenosis (

conclusionGLS correlates with established markers of myocardial fibrosis. However, widespread utility of single GLS measurements may be limited by overlap between disease states and its inability to predict clinical outcomes beyond current established markers.© RSNA, 2019

Identifiers

PMID33778518
PMCPMC7977929
OpenAlexW2988735858

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.