Free-breathing Cardiorespiratory Synchronized Cine MRI for Assessment of Left and Right Ventricular Volume and Function in Sedated Children and Adolescents with Impaired Breath-holding Capacity.

purposeTo prospectively compare left ventricular and right ventricular volume, function, and image quality of a free-breathing (FB) cardiorespiratory synchronized balanced steady-state free precession cine MRI sequence with that of a standard of reference breath-hold (BH) technique in sedated children and adolescents who are unable to perform BHs. MATERIALS AND

methodsCohort 1 included 30 patients able to perform BHs (mean age, 19 years; age range, 9-69 years). Cohort 1 underwent both BH and FB cine short-axis imaging with identical acquisition parameters. Cohort 2 included 63 patients unable to perform BHs (50 sedated patients [mean age, 9 years; age range, 4 months to 28 years], 13 unsedated patients [mean age, 21 years; age range, 8-58 years]). Cohort 2 underwent FB cine imaging in multiple views with spatiotemporal resolution equivalent to BH imaging. Comparative quantitative analysis was performed for left ventricular and right ventricular volumes in cohort 1 and for qualitative image quality scores in all patients.

resultsGlobal left ventricular and right ventricular volumetric indexes and image quality scores were comparable between BH and FB sequences in cohort 1. FB image quality was graded as excellent (37 sequences), good (197 sequences), adequate (26 sequences), and suboptimal (three sequences) for 263 cine sequences in cohort 2. In cohort 1, de facto image acquisition time for FB (6.1 minutes ± 1.9 [standard deviation]) was comparable to the equivalent for BH (6.1 minutes ± 2.6) for a stack of 14 sections.

conclusionIn cohorts of sedated children, adolescents, and young adults unable to perform BHs consistently, left ventricular and right ventricular volumes and function were comparable and image quality was noninferior between FB and standard of reference BH techniques.© RSNA, 2019.