ArticleRadiology. Cardiothoracic imaging2019
Stress Myocardial Perfusion PET Provides Incremental Risk Prediction in Patients with and Patients without Diabetes.
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Article in Radiology. Cardiothoracic imaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6citing papers in PubMed
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6 citing papers in PubMed, 11 citations in OpenAlex.
- Incremental prognostic value of ischemic score quantified by stress dynamic CT myocardial perfusion in patients with and without diabetes mellitus.Scientific reports · 2025Article
- Hunting for a coronary artery disease diagnosis in asymptomatic patients with diabetes mellitus: if, how and when.Cardiovascular diabetology · 2025Review
- Independent prognostic significance of myocardial flow reserve over coronary artery calcium, myocardial perfusion, and clinical variables in patients without known coronary artery disease, according to diabetes status.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2025Article
- Cardiovascular Magnetic Resonance Imaging as an Adjunct to the Evaluation of Cardiovascular Involvement in Diabetes Mellitus.Journal of personalized medicine · 2023Review
- Advanced Echocardiography Techniques: The Future Stethoscope of Systemic Diseases.Current problems in cardiology · 2022Review
- The adverse impact of coronary artery disease on left ventricle systolic and diastolic function in patients with type 2 diabetes mellitus: a 3.0T CMR study.Cardiovascular diabetology · 2022Article
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Authors and funding
13 authors at 2 institutions in 2 countries.
Hicham SkaliCardiovascular Division and Department of Radiology, Harvard Medical School, Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115 (H.S., M.F.D., R.B., S.D.); University of Ottawa Heart Institute, Ottawa, Canada (B.J.C., R.S.B.); Cedars-Sinai Medical Center, Los Angeles, Calif (D.S.B., G.G.); New York-Presbyterian Hospital/Weill Cornell Medical College, New York, NY (J.K.M.); Niagara Falls Memorial Medical Center, Niagara Falls, NY (M.M.); Geisinger Health System, Danville, Pa (B.W.); Baptist Health South Florida, Miami, Fla (E.V.); and Emory University School of Medicine, Emory Clinical Cardiovascular Research Institute, Atlanta, Ga (L.J.S.).ORCID 0000-0002-5629-4138
Marcelo F Di CarliCardiovascular Division and Department of Radiology, Harvard Medical School, Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115 (H.S., M.F.D., R.B., S.D.); University of Ottawa Heart Institute, Ottawa, Canada (B.J.C., R.S.B.); Cedars-Sinai Medical Center, Los Angeles, Calif (D.S.B., G.G.); New York-Presbyterian Hospital/Weill Cornell Medical College, New York, NY (J.K.M.); Niagara Falls Memorial Medical Center, Niagara Falls, NY (M.M.); Geisinger Health System, Danville, Pa (B.W.); Baptist Health South Florida, Miami, Fla (E.V.); and Emory University School of Medicine, Emory Clinical Cardiovascular Research Institute, Atlanta, Ga (L.J.S.).
Ron BlanksteinCardiovascular Division and Department of Radiology, Harvard Medical School, Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115 (H.S., M.F.D., R.B., S.D.); University of Ottawa Heart Institute, Ottawa, Canada (B.J.C., R.S.B.); Cedars-Sinai Medical Center, Los Angeles, Calif (D.S.B., G.G.); New York-Presbyterian Hospital/Weill Cornell Medical College, New York, NY (J.K.M.); Niagara Falls Memorial Medical Center, Niagara Falls, NY (M.M.); Geisinger Health System, Danville, Pa (B.W.); Baptist Health South Florida, Miami, Fla (E.V.); and Emory University School of Medicine, Emory Clinical Cardiovascular Research Institute, Atlanta, Ga (L.J.S.).ORCID 0000-0002-8393-6562
Benjamin J ChowCardiovascular Division and Department of Radiology, Harvard Medical School, Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115 (H.S., M.F.D., R.B., S.D.); University of Ottawa Heart Institute, Ottawa, Canada (B.J.C., R.S.B.); Cedars-Sinai Medical Center, Los Angeles, Calif (D.S.B., G.G.); New York-Presbyterian Hospital/Weill Cornell Medical College, New York, NY (J.K.M.); Niagara Falls Memorial Medical Center, Niagara Falls, NY (M.M.); Geisinger Health System, Danville, Pa (B.W.); Baptist Health South Florida, Miami, Fla (E.V.); and Emory University School of Medicine, Emory Clinical Cardiovascular Research Institute, Atlanta, Ga (L.J.S.).ORCID 0000-0001-8631-0234
Rob S BeanlandsCardiovascular Division and Department of Radiology, Harvard Medical School, Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115 (H.S., M.F.D., R.B., S.D.); University of Ottawa Heart Institute, Ottawa, Canada (B.J.C., R.S.B.); Cedars-Sinai Medical Center, Los Angeles, Calif (D.S.B., G.G.); New York-Presbyterian Hospital/Weill Cornell Medical College, New York, NY (J.K.M.); Niagara Falls Memorial Medical Center, Niagara Falls, NY (M.M.); Geisinger Health System, Danville, Pa (B.W.); Baptist Health South Florida, Miami, Fla (E.V.); and Emory University School of Medicine, Emory Clinical Cardiovascular Research Institute, Atlanta, Ga (L.J.S.).
Daniel S BermanCardiovascular Division and Department of Radiology, Harvard Medical School, Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115 (H.S., M.F.D., R.B., S.D.); University of Ottawa Heart Institute, Ottawa, Canada (B.J.C., R.S.B.); Cedars-Sinai Medical Center, Los Angeles, Calif (D.S.B., G.G.); New York-Presbyterian Hospital/Weill Cornell Medical College, New York, NY (J.K.M.); Niagara Falls Memorial Medical Center, Niagara Falls, NY (M.M.); Geisinger Health System, Danville, Pa (B.W.); Baptist Health South Florida, Miami, Fla (E.V.); and Emory University School of Medicine, Emory Clinical Cardiovascular Research Institute, Atlanta, Ga (L.J.S.).ORCID 0000-0002-3793-9578
Guido GermanoCardiovascular Division and Department of Radiology, Harvard Medical School, Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115 (H.S., M.F.D., R.B., S.D.); University of Ottawa Heart Institute, Ottawa, Canada (B.J.C., R.S.B.); Cedars-Sinai Medical Center, Los Angeles, Calif (D.S.B., G.G.); New York-Presbyterian Hospital/Weill Cornell Medical College, New York, NY (J.K.M.); Niagara Falls Memorial Medical Center, Niagara Falls, NY (M.M.); Geisinger Health System, Danville, Pa (B.W.); Baptist Health South Florida, Miami, Fla (E.V.); and Emory University School of Medicine, Emory Clinical Cardiovascular Research Institute, Atlanta, Ga (L.J.S.).
James K MinCardiovascular Division and Department of Radiology, Harvard Medical School, Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115 (H.S., M.F.D., R.B., S.D.); University of Ottawa Heart Institute, Ottawa, Canada (B.J.C., R.S.B.); Cedars-Sinai Medical Center, Los Angeles, Calif (D.S.B., G.G.); New York-Presbyterian Hospital/Weill Cornell Medical College, New York, NY (J.K.M.); Niagara Falls Memorial Medical Center, Niagara Falls, NY (M.M.); Geisinger Health System, Danville, Pa (B.W.); Baptist Health South Florida, Miami, Fla (E.V.); and Emory University School of Medicine, Emory Clinical Cardiovascular Research Institute, Atlanta, Ga (L.J.S.).
Michael MerhigeCardiovascular Division and Department of Radiology, Harvard Medical School, Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115 (H.S., M.F.D., R.B., S.D.); University of Ottawa Heart Institute, Ottawa, Canada (B.J.C., R.S.B.); Cedars-Sinai Medical Center, Los Angeles, Calif (D.S.B., G.G.); New York-Presbyterian Hospital/Weill Cornell Medical College, New York, NY (J.K.M.); Niagara Falls Memorial Medical Center, Niagara Falls, NY (M.M.); Geisinger Health System, Danville, Pa (B.W.); Baptist Health South Florida, Miami, Fla (E.V.); and Emory University School of Medicine, Emory Clinical Cardiovascular Research Institute, Atlanta, Ga (L.J.S.).
Brent WilliamsCardiovascular Division and Department of Radiology, Harvard Medical School, Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115 (H.S., M.F.D., R.B., S.D.); University of Ottawa Heart Institute, Ottawa, Canada (B.J.C., R.S.B.); Cedars-Sinai Medical Center, Los Angeles, Calif (D.S.B., G.G.); New York-Presbyterian Hospital/Weill Cornell Medical College, New York, NY (J.K.M.); Niagara Falls Memorial Medical Center, Niagara Falls, NY (M.M.); Geisinger Health System, Danville, Pa (B.W.); Baptist Health South Florida, Miami, Fla (E.V.); and Emory University School of Medicine, Emory Clinical Cardiovascular Research Institute, Atlanta, Ga (L.J.S.).
Emir VeledarCardiovascular Division and Department of Radiology, Harvard Medical School, Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115 (H.S., M.F.D., R.B., S.D.); University of Ottawa Heart Institute, Ottawa, Canada (B.J.C., R.S.B.); Cedars-Sinai Medical Center, Los Angeles, Calif (D.S.B., G.G.); New York-Presbyterian Hospital/Weill Cornell Medical College, New York, NY (J.K.M.); Niagara Falls Memorial Medical Center, Niagara Falls, NY (M.M.); Geisinger Health System, Danville, Pa (B.W.); Baptist Health South Florida, Miami, Fla (E.V.); and Emory University School of Medicine, Emory Clinical Cardiovascular Research Institute, Atlanta, Ga (L.J.S.).
Leslee J ShawCardiovascular Division and Department of Radiology, Harvard Medical School, Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115 (H.S., M.F.D., R.B., S.D.); University of Ottawa Heart Institute, Ottawa, Canada (B.J.C., R.S.B.); Cedars-Sinai Medical Center, Los Angeles, Calif (D.S.B., G.G.); New York-Presbyterian Hospital/Weill Cornell Medical College, New York, NY (J.K.M.); Niagara Falls Memorial Medical Center, Niagara Falls, NY (M.M.); Geisinger Health System, Danville, Pa (B.W.); Baptist Health South Florida, Miami, Fla (E.V.); and Emory University School of Medicine, Emory Clinical Cardiovascular Research Institute, Atlanta, Ga (L.J.S.).ORCID 0000-0003-1268-1491
Sharmila DorbalaCardiovascular Division and Department of Radiology, Harvard Medical School, Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115 (H.S., M.F.D., R.B., S.D.); University of Ottawa Heart Institute, Ottawa, Canada (B.J.C., R.S.B.); Cedars-Sinai Medical Center, Los Angeles, Calif (D.S.B., G.G.); New York-Presbyterian Hospital/Weill Cornell Medical College, New York, NY (J.K.M.); Niagara Falls Memorial Medical Center, Niagara Falls, NY (M.M.); Geisinger Health System, Danville, Pa (B.W.); Baptist Health South Florida, Miami, Fla (E.V.); and Emory University School of Medicine, Emory Clinical Cardiovascular Research Institute, Atlanta, Ga (L.J.S.).ORCID 0000-0003-1462-1185
Cedars-Sinai Medical Center · USNewYork–Presbyterian Hospital · US
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate the prognostic value of myocardial perfusion PET in patients with and patients without diabetes mellitus. MATERIALS AND
methodsThe authors performed a retrospective analysis of prospectively acquired data from a multicenter registry cohort of 7061 patients, including 1966 with diabetes mellitus, who underwent clinically indicated rest-stress rubidium 82 (
resultsIn multivariable models adjusting for established clinical predictors, increasing magnitude of stress myocardial perfusion abnormality was associated with greater risk of cardiac death in patients with diabetes (hazard ratio [HR]: 7.2; 95% confidence interval [CI]: 3.1, 16.8) for severely abnormal myocardium compared with normal myocardium. The addition of stress myocardial perfusion imaging results significantly improved the fit of a clinical model for predicting cardiac death in patients with and patients without diabetes. Myocardial perfusion PET improved risk reclassification for cardiac death in patients with diabetes (category-based net reclassification index: 0.39; 95% CI: 0.15, 0.60,
conclusionIn a large cohort of patients referred for clinical
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