Evidence map›Paper›PMID 33778497›Full record

ArticleRadiology. Cardiothoracic imaging2019

Myocardial Late Iodine Enhancement and Extracellular Volume Quantification with Dual-Layer Spectral Detector Dual-Energy Cardiac CT.

Seitaro Oda, Takafumi Emoto, Takeshi Nakaura, Masafumi Kidoh, Daisuke Utsunomiya, Yoshinori Funama, Yasunori Nagayama, Seiji Takashio, Mitsuharu Ueda, Taro Yamashita and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiology. Cardiothoracic imaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 1 synthesis or guideline pooled it, 96 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Extracellular volume fraction by cardiac computed tomography (ECVEuropean heart journal. Imaging methods and practice · 2026
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Advanced myocardial characterization and function with cardiac CT.The international journal of cardiovascular imaging · 2026
    Review
  14. Clinical application of cardiac computed tomography in cardiomyopathy.The international journal of cardiovascular imaging · 2026
    Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Seitaro OdaDepartments of Diagnostic Radiology (S.O., T.N., M.K., D.U., Y.N., Y.Y.), Medical Physics (Y.F.), Cardiology (S.T., K.T.), and Neurology (M.U., T.Y., Y.A.), Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjyo, Chuo-ku, Kumamoto 860-8556, Japan; and Department of Central Radiology, Kumamoto University Hospital, Kumamoto, Japan (T.E.).ORCID 0000-0003-4101-5113
Takafumi EmotoDepartments of Diagnostic Radiology (S.O., T.N., M.K., D.U., Y.N., Y.Y.), Medical Physics (Y.F.), Cardiology (S.T., K.T.), and Neurology (M.U., T.Y., Y.A.), Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjyo, Chuo-ku, Kumamoto 860-8556, Japan; and Department of Central Radiology, Kumamoto University Hospital, Kumamoto, Japan (T.E.).ORCID 0000-0002-3258-4085
Takeshi NakauraDepartments of Diagnostic Radiology (S.O., T.N., M.K., D.U., Y.N., Y.Y.), Medical Physics (Y.F.), Cardiology (S.T., K.T.), and Neurology (M.U., T.Y., Y.A.), Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjyo, Chuo-ku, Kumamoto 860-8556, Japan; and Department of Central Radiology, Kumamoto University Hospital, Kumamoto, Japan (T.E.).ORCID 0000-0002-9010-0341
Masafumi KidohDepartments of Diagnostic Radiology (S.O., T.N., M.K., D.U., Y.N., Y.Y.), Medical Physics (Y.F.), Cardiology (S.T., K.T.), and Neurology (M.U., T.Y., Y.A.), Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjyo, Chuo-ku, Kumamoto 860-8556, Japan; and Department of Central Radiology, Kumamoto University Hospital, Kumamoto, Japan (T.E.).ORCID 0000-0002-9589-7054
Daisuke UtsunomiyaDepartments of Diagnostic Radiology (S.O., T.N., M.K., D.U., Y.N., Y.Y.), Medical Physics (Y.F.), Cardiology (S.T., K.T.), and Neurology (M.U., T.Y., Y.A.), Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjyo, Chuo-ku, Kumamoto 860-8556, Japan; and Department of Central Radiology, Kumamoto University Hospital, Kumamoto, Japan (T.E.).ORCID 0000-0002-1723-1724
Yoshinori FunamaDepartments of Diagnostic Radiology (S.O., T.N., M.K., D.U., Y.N., Y.Y.), Medical Physics (Y.F.), Cardiology (S.T., K.T.), and Neurology (M.U., T.Y., Y.A.), Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjyo, Chuo-ku, Kumamoto 860-8556, Japan; and Department of Central Radiology, Kumamoto University Hospital, Kumamoto, Japan (T.E.).ORCID 0000-0003-1797-9625
Yasunori NagayamaDepartments of Diagnostic Radiology (S.O., T.N., M.K., D.U., Y.N., Y.Y.), Medical Physics (Y.F.), Cardiology (S.T., K.T.), and Neurology (M.U., T.Y., Y.A.), Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjyo, Chuo-ku, Kumamoto 860-8556, Japan; and Department of Central Radiology, Kumamoto University Hospital, Kumamoto, Japan (T.E.).ORCID 0000-0003-3280-7346
Seiji TakashioDepartments of Diagnostic Radiology (S.O., T.N., M.K., D.U., Y.N., Y.Y.), Medical Physics (Y.F.), Cardiology (S.T., K.T.), and Neurology (M.U., T.Y., Y.A.), Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjyo, Chuo-ku, Kumamoto 860-8556, Japan; and Department of Central Radiology, Kumamoto University Hospital, Kumamoto, Japan (T.E.).ORCID 0000-0002-6201-0701
Mitsuharu UedaDepartments of Diagnostic Radiology (S.O., T.N., M.K., D.U., Y.N., Y.Y.), Medical Physics (Y.F.), Cardiology (S.T., K.T.), and Neurology (M.U., T.Y., Y.A.), Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjyo, Chuo-ku, Kumamoto 860-8556, Japan; and Department of Central Radiology, Kumamoto University Hospital, Kumamoto, Japan (T.E.).ORCID 0000-0002-6814-0582
Taro YamashitaDepartments of Diagnostic Radiology (S.O., T.N., M.K., D.U., Y.N., Y.Y.), Medical Physics (Y.F.), Cardiology (S.T., K.T.), and Neurology (M.U., T.Y., Y.A.), Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjyo, Chuo-ku, Kumamoto 860-8556, Japan; and Department of Central Radiology, Kumamoto University Hospital, Kumamoto, Japan (T.E.).
Kenichi TsujitaDepartments of Diagnostic Radiology (S.O., T.N., M.K., D.U., Y.N., Y.Y.), Medical Physics (Y.F.), Cardiology (S.T., K.T.), and Neurology (M.U., T.Y., Y.A.), Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjyo, Chuo-ku, Kumamoto 860-8556, Japan; and Department of Central Radiology, Kumamoto University Hospital, Kumamoto, Japan (T.E.).
Yukio AndoDepartments of Diagnostic Radiology (S.O., T.N., M.K., D.U., Y.N., Y.Y.), Medical Physics (Y.F.), Cardiology (S.T., K.T.), and Neurology (M.U., T.Y., Y.A.), Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjyo, Chuo-ku, Kumamoto 860-8556, Japan; and Department of Central Radiology, Kumamoto University Hospital, Kumamoto, Japan (T.E.).ORCID 0000-0001-7115-9105
Yasuyuki YamashitaDepartments of Diagnostic Radiology (S.O., T.N., M.K., D.U., Y.N., Y.Y.), Medical Physics (Y.F.), Cardiology (S.T., K.T.), and Neurology (M.U., T.Y., Y.A.), Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjyo, Chuo-ku, Kumamoto 860-8556, Japan; and Department of Central Radiology, Kumamoto University Hospital, Kumamoto, Japan (T.E.).ORCID 0000-0002-2905-1093
Kumamoto University Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo explore the usefulness of myocardial late iodine enhancement (LIE) and extracellular volume (ECV) quantification by using dual-energy cardiac CT. MATERIALS AND

methodsIn this single-center retrospective study, a total of 40 patients were evaluated with LIE CT by using a dual-layer spectral detector CT system. Among these, 21 also underwent cardiac MRI. Paired image sets were created by using standard imaging at 120 kVp, virtual monochromatic imaging (VMI) at 50 keV, and iodine density imaging. The contrast-to-noise ratio and image quality were then compared. Two observers assessed the presence of LIE and calculated the interobserver agreements. Agreement between CT and cardiac MRI when detecting late-enhancing lesions and calculating the ECV was also assessed.

resultsThe contrast-to-noise ratio was significantly higher by using VMI than by using standard 120-kVp imaging, and the mean visual image quality score was significantly higher by using VMI than by using either standard or iodine density imaging. For interobserver agreement of visual detection of LIE, the agreement for VMI was excellent and the κ value (κ, 0.87) was higher than that for the standard 120-kVp (κ, 0.70) and iodine density (κ, 0.83) imaging. For detecting late-enhancing lesions, agreement with cardiac MRI was excellent by using VMI (κ, 0.90) and iodine density imaging (κ, 0.87) but was only good by using standard 120-kVp imaging (κ, 0.66). Quantitative comparisons of the ECV calculations by using CT and cardiac MRI showed excellent correlation (

conclusionDual-energy cardiac CT can assess myocardial LIE and quantify ECV, with results comparable to those obtained by using cardiac MRI.© RSNA, 2019See also the commentary by Litt in this issue.

Identifiers

PMID33778497
PMCPMC7977749
OpenAlexW2941953158

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.