ArticleJOR spine2021
Electrospun biodegradable poly(ε-caprolactone) membranes for annulus fibrosus repair: Long-term material stability and mechanical competence.
Article in JOR spine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Enzymatic chemonucleolysis for lumbar disc herniation-an assessment of historical and contemporary efficacy and safety: a systematic review and meta-analysis.Scientific reports · 2024Pooled it
- Engineering extracellular matrix-based hydrogels for intervertebral disc regeneration.Frontiers in bioengineering and biotechnology · 2025Review
- Article
- Characterization of Gelatin-Polycaprolactone Membranes by Electrospinning.Biomimetics (Basel, Switzerland) · 2024Article
- Hydrogel-Based Strategies for Intervertebral Disc Regeneration: Advances, Challenges and Clinical Prospects.Gels (Basel, Switzerland) · 2024Review
- Recent advances in the repair of degenerative intervertebral disc for preclinical applications.Frontiers in bioengineering and biotechnology · 2023Review
- Electrospun biodegradable poly(ε-caprolactone) membranes for annulus fibrosus repair: Long-term material stability and mechanical competence.JOR spine · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundElectrospun (ES) poly(ɛ-caprolactone) (PCL) is widely used to provide critical mechanical support in tissue engineering and regenerative medicine applications. Therefore, there is a clear need for understanding the change in the mechanical response of the membranes as the material degrades in physiological conditions. STUDY
designES membranes with fiber diameters from 1.6 to 6.7 μm were exposed to in vitro conditions at 37°C in Dulbecco's modified Eagle's medium (DMEM) or dry for up to 6 months.
methodsDuring this period, the mechanical properties were assessed using cyclic mechanical loading, and material properties such as crystallinity and ester bond degradation were measured.
resultsNo significant difference was found for any parameters between samples kept dry and in DMEM. The increase in crystallinity was linear with time, while the ester bond degradation showed an inverse logarithmic correlation with time. All samples showed an increase in modulus with exposure time for the first loading cycle. Modulus changes for the consecutive loading cycles showed a nonlinear relationship to the exposure time that depended on membrane type and maximum strain. In addition, the recovered elastic range showed an expected increase with the maximum strain reached. The mechanical response of ES membranes was compared to experimental tensile properties of the human annulus fibrosus tissue and an in silico model of the intervertebral disk. The modulus of the tested membranes was at the lower range of the values found in literature, while the elastically recoverable strain after preconditioning for all membrane types lies within the desired strain range for this application.
conclusionThe long-term assessment under application-specific conditions allowed to establish the mechanical competence of the electrospun PCL membranes. It can be concluded that with the use of appropriate fixation, the membranes can be used to create a seal on the damaged AF.
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