ArticleEnvironmental epidemiology (Philadelphia, Pa.)2020
A cohort study on long-term exposure to air pollution and incidence of liver cirrhosis.
Article in Environmental epidemiology (Philadelphia, Pa.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Long-Term Exposure to Fine Particulate Matter and the Risk of Chronic Liver Diseases: A Meta-Analysis of Observational Studies.International journal of environmental research and public health · 2022Pooled it
- Hepatotoxicity Prediction and Multi-omics Reveal Mitochondrial and Lipid Metabolic Dysregulation in PMEnvironment & health (Washington, D.C.) · 2026Article
- Long-term exposure to air pollution and liver fibrosis in the elderly with MASLD.Scientific reports · 2025Article
- Long-term exposure to ambient fine particulate matter and risk of liver cancer in the NIH-AARP Diet and Health Study.Environment international · 2024Article
- Non-linear association between long-term air pollution exposure and risk of metabolic dysfunction-associated steatotic liver disease.Environmental health and preventive medicine · 2024Article
- Long-term exposure to air pollution and prevalent nonalcoholic fatty liver disease.Environmental epidemiology (Philadelphia, Pa.) · 2023Article
- Short-Term Exposure to PMToxics · 2023Article
- Self-Reported Primary Cooking Fuels Use and Risk of Chronic Digestive Diseases: A Prospective Cohort Study of 0.5 Million Chinese Adults.Environmental health perspectives · 2023Article
- Sex-Dependent Responses to Maternal Exposure to PMAntioxidants (Basel, Switzerland) · 2022Article
- Epidemiology of liver cirrhosis and associated complications: Current knowledge and future directions.World journal of gastroenterology · 2022Review
- Exposure to Air Pollution and Survival in Follow-Up after Hepatocellular Carcinoma.Liver cancer · 2022Article
- Murine in utero exposure to simulated complex urban air pollution disturbs offspring gut maturation and microbiota during intestinal suckling-to-weaning transition in a sex-dependent manner.Particle and fibre toxicology · 2022Article
- A global association between Covid-19 cases and airborne particulate matter at regional level.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cirrhosis is an advanced liver disease affecting millions of people worldwide, involving high healthcare costs. Despite experimental evidence suggesting a possible role of airborne pollutants in liver diseases, epidemiological studies are lacking. We aimed at investigating the association between exposure to air pollutants and incidence of cirrhosis in a large population-based cohort in Rome.
methodsWe used an administrative cohort established from the 2001 census. We included all adults of 30 years of age or older who were free of cirrhosis, resulting in a study population of over 1.2 million subjects. Follow-up of the subjects ended on 31 December 2015. We ascertained incident cases of cirrhosis from regional mortality and hospital discharge registries using a validated algorithm. We assessed exposure of the subjects to PM
resultsWe observed 10,111 incident cases of cirrhosis, with a crude incidence rate of 67 × 100,000 person-years. Long-term exposure to all pollutants tested was significantly associated with cirrhosis, e.g., PM
conclusionsOur findings suggest a possible contribution of air pollution to the development of cirrhosis.
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