Evidence map›Paper›PMID 33778331›Full record

ArticleToxicology communications2020

Acute Liver Failure of unclear cause? Acetaminophen-protein adducts make the diagnosis.

Michael E Mullins, Laura P James

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicology communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 98% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Michael E MullinsToxicology Section, Division of Emergency Medicine, Washington University School of Medicine; Saint Louis, Missouri, USA.
Laura P JamesDepartment of Pediatrics, University of Arkansas for Medical Sciences and Arkansas Children's Hospital Research Institute, Little Rock, AR, USA.
University of Arkansas for Medical Sciences · USWashington University in St. Louis · US

Funding

Adduct Dipstick for Diagnosis of Acetaminophen ToxicityR42DK079387 · NIDDK · ACETAMINOPHEN TOXICITY DIAGNOSTICS, LLC · PI JAMES, LAURA PHILLIPS · 2011 to 2018
$4.4M
Identification of new mechanistic biomarkers of adverse responses to acetaminopheR01DK081406 · NIDDK · ARKANSAS CHILDREN'S HOSPITAL RES INST · PI JAMES, LAURA P · 2009 to 2013
$1.9M
Evaluation of a Biomarker for Acetaminophen ToxicityR03DK067999 · NIDDK · ARKANSAS CHILDREN'S HOSPITAL RES INST · PI JAMES, LAURA P · 2004 to 2005
$262k
NIDDK NIH HHS R01 DK081406NIDDK NIH HHS R03 DK067999NIDDK NIH HHS R42 DK079387
6 · The paper itself

Abstract

Acetaminophen poisoning remains a leading cause of acute liver failure. Some cases may be difficult to diagnose when clinical findings are equivocal, the patient's history is misleading or incomplete, or the acetaminophen concentration is low or undetectable at arrival to care. We describe a case of a medically complicated young child whose acute liver failure had two of these features. Measurement of acetaminophen-protein adducts confirmed acetaminophen as the primary cause of her liver failure.

Indexed as

AcetaminophenAcute Liver FailureCase reportDiagnosis

Identifiers

PMID33778331
PMCPMC7993646
OpenAlexW3008332099

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.