Evidence map›Paper›PMID 33778327›Full record

ArticleJBMR plus2021

Longitudinal Functional Study of Murine Aging: A Resource for Future Study Designs.

Daniel S Evans, Monique N O'Leary, Ryan Murphy, Minna Schmidt, Kristin Koenig, Michael Presley, Brittany Garrett, Ha-Neui Kim, Li Han, Emmeline C Academia and 15 more

Open access · goldAbstract read
In one paragraph

Article in JBMR plus, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Article
  3. The cold truth: torpor as a confound in studies of caloric restriction.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2025
    Review
  4. Article
  5. Article
  6. Article
  7. Animal Models Relevant for Geroscience: Current Trends and Future Perspectives in Biomarkers, and Measures of Biological Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024
    Review
  8. Quantifying the Impact of Co-Housing on Murine Aging Studies.bioRxiv : the preprint server for biology · 2024
    Article
  9. Article
  10. Review
  11. The DAging cell · 2023
    Article
  12. Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 4 institutions in 1 country.

Daniel S EvansCalifornia Pacific Medical Center Research Institute San Francisco CA USA.
Monique N O'LearyThe Buck Institute for Research on Aging Novato CA USA.
Ryan MurphyThe Buck Institute for Research on Aging Novato CA USA.
Minna SchmidtThe Buck Institute for Research on Aging Novato CA USA.
Kristin KoenigThe Buck Institute for Research on Aging Novato CA USA.
Michael PresleyThe Buck Institute for Research on Aging Novato CA USA.
Brittany GarrettThe Buck Institute for Research on Aging Novato CA USA.
Ha-Neui KimUniversity of Arkansas for Medical Sciences Little Rock AR USA.ORCID https://orcid.org/0000-0003-2498-6700
Li HanUniversity of Arkansas for Medical Sciences Little Rock AR USA.
Emmeline C AcademiaThe Buck Institute for Research on Aging Novato CA USA.
Matt J LayeThe Buck Institute for Research on Aging Novato CA USA.
Daniel EdgarThe Buck Institute for Research on Aging Novato CA USA.
Christopher A ZambataroThe Buck Institute for Research on Aging Novato CA USA.
Tracey BarhydtThe Buck Institute for Research on Aging Novato CA USA.
Colleen M DeweyThe Buck Institute for Research on Aging Novato CA USA.
Jarrott MayfieldThe Buck Institute for Research on Aging Novato CA USA.
Joy WilsonThe Buck Institute for Research on Aging Novato CA USA.
Silvestre AlavezThe Buck Institute for Research on Aging Novato CA USA.
Mark LucanicGerostate Alpha Novato CA USA.
Brian K KennedyThe Buck Institute for Research on Aging Novato CA USA.
Maria AlmeidaUniversity of Arkansas for Medical Sciences Little Rock AR USA.
Julie K AndersenThe Buck Institute for Research on Aging Novato CA USA.
Pankaj KapahiThe Buck Institute for Research on Aging Novato CA USA.
Gordon J LithgowThe Buck Institute for Research on Aging Novato CA USA.
Simon MelovThe Buck Institute for Research on Aging Novato CA USA.ORCID https://orcid.org/0000-0001-8554-2834
Buck Institute for Research on Aging · USUniversity of Arkansas for Medical Sciences · USCalifornia Pacific Medical Center · USMarin Community Foundation · US

Funding

Integrative Resource to Develop Translational Strategies to Promote LongevityU24AG051129 · NIA · CALIFORNIA PACIFIC MED CTR RES INSTITUTE · PI CUMMINGS, STEVEN RON, EVANS, DANIEL SPENCER · 2015 to 2019
$5.3M
Role of FoxOs in Skeletal Homeostasis- ResubmissionR01AR056679 · NIAMS · UNIV OF ARKANSAS FOR MED SCIS · PI ALMEIDA, MARIA JOSE · 2010 to 2020
$3.6M
Integrative Omics to enhance therapeutics development for healthy agingUH3AG064706 · NIA · TRANSLATIONAL GENOMICS RESEARCH INST · PI MILLER, RICHARD A, SCHORK, NICHOLAS JOSEPH · 2021 to 2024
$3.3M
NIAMS NIH HHS R01 AR056679NIA NIH HHS U24 AG051129NIA NIH HHS UH3 AG064706
6 · The paper itself

Abstract

Aging is characterized by systemic declines in tissue and organ functions. Interventions that slow these declines represent promising therapeutics to protect against age-related disease and improve the quality of life. In this study, several interventions associated with lifespan extension in invertebrates or improvement of age-related disease were tested in mouse models to determine if they were effective in slowing tissue aging in a broad spectrum of functional assays. Benzoxazole, which extends the lifespan of

Indexed as

AGINGBONEMOLECULAR COMPUTED TOMOGRAPHY (mCT)OSTEOBLASTSOSTEOCLASTS

Identifiers

PMID33778327
PMCPMC7990142
OpenAlexW3122485118

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.