Evidence map›Paper›PMID 33778212›Full record

ArticleJACC. Basic to translational science2021

A Role for Polo-Like Kinase 4 in Vascular Fibroblast Cell-Type Transition.

Jing Li, Go Urabe, Yitao Huang, Mengxue Zhang, Bowen Wang, Lynn Marcho, Hongtao Shen, K Craig Kent, Lian-Wang Guo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Basic to translational science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. SREBP1 regulatesMolecular therapy. Nucleic acids · 2022
    Article
  6. Review
  7. JACC. Basic to translational science · 2021
    Article
4 · The record

Corrections and comments

  • Commented on by
    2021
5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Jing LiDepartment of Surgery, School of Medicine, University of Virginia, Charlottesville, Virginia, USA.
Go UrabeDepartment of Surgery, School of Medicine, University of Virginia, Charlottesville, Virginia, USA.
Yitao HuangDepartment of Surgery, School of Medicine, University of Virginia, Charlottesville, Virginia, USA.
Mengxue ZhangDepartment of Surgery, School of Medicine, University of Virginia, Charlottesville, Virginia, USA.
Bowen WangDepartment of Surgery, School of Medicine, University of Virginia, Charlottesville, Virginia, USA.
Lynn MarchoDavis Heart and Lung Research Institute, Wexner Medical Center, Ohio State University, Columbus, Ohio, USA.
Hongtao ShenDepartment of Surgery, School of Medicine, University of Virginia, Charlottesville, Virginia, USA.
K Craig KentDepartment of Surgery, School of Medicine, University of Virginia, Charlottesville, Virginia, USA.
Lian-Wang GuoDepartment of Surgery, School of Medicine, University of Virginia, Charlottesville, Virginia, USA.
University of Virginia · USThe Ohio State University Wexner Medical Center · USUniversity of Wisconsin–Madison · US

Funding

BET Bromodomain proteins as Novel Epigenetic Targets for prevention of Intimal Hyperplasia after Vascular SurgeryR01HL133665 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI GUO, LIANWANG · 2016 to 2019
$1.6M
Master epigenetic regulators and retinal degenerative diseaseR01EY029809 · NEI · UNIVERSITY OF VIRGINIA · PI GUO, LIANWANG · 2019 to 2022
$1.6M
NEI NIH HHS R01 EY029809NHLBI NIH HHS R01 HL133665
6 · The paper itself

Abstract

Polo-like kinase 4 (PLK4) is canonically known for its cytoplasmic function in centriole duplication. Here we show a noncanonical PLK4 function of regulating the transcription factor SRF's nuclear activity and associated myofibroblast-like cell-type transition. In this context, we have further found that PLK4's phosphorylation and transcription are respectively regulated by PDGF receptor and epigenetic factor BRD4. Furthermore, in vivo experiments suggest PLK4 inhibition as a potential approach to mitigating vascular fibrosis.

Indexed as

AA, PDGF-AABET, bromo/extraterminal domain–containing proteinBRD4BRD4, bromodomain protein 4CenB, centrinone-BEEL, external elastic laminafibroblast cell-type transitionJQ1, a BET family–selective epigenetic modulator drugMRTF-A, myocardin-related transcription factor APDGF, platelet-derived growth factorPDGF receptorPDGFR, PDGF receptorPLK4PLK, polo-like kinaseSRFSRF, serum response factorαSMA, α-smooth muscle actin

Identifiers

PMID33778212
PMCPMC7987547
OpenAlexW3138938712

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.