Evidence map›Paper›PMID 33778208›Full record

ArticleJACC. Basic to translational science2021

First-in-Human Experience of Mechanical Preload Control in Patients With HFpEF During Exercise.

Daniel W Kaiser, Patrick Platzer, Katie Miyashiro, James Canfield, Rupal Patel, Dandan Liu, Frederick St Goar, Clayton A Kaiser

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Basic to translational science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Turning Pressure Into Success: Preload Restriction in HFpEF?JACC. Basic to translational science · 2021
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Daniel W KaiserDepartment of Respiratory Therapy, El Camino Hospital, Mountain View, California.
Patrick PlatzerDepartment of Cardiovascular Medicine, Saint Thomas Hospital, Nashville, Tennessee, USA.
Katie MiyashiroCardioFlow Technologies, Nashville, Tennessee, USA.
James CanfieldDepartment of Respiratory Therapy, El Camino Hospital, Mountain View, California.
Rupal PatelDepartment of Respiratory Therapy, El Camino Hospital, Mountain View, California.
Dandan LiuDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Frederick St GoarDepartment of Respiratory Therapy, El Camino Hospital, Mountain View, California.
Clayton A KaiserDepartment of Cardiovascular Medicine, Saint Thomas Hospital, Nashville, Tennessee, USA.
El Camino Hospital · USSaint Thomas West Hospital · USCardio Flow (United States) · USVanderbilt University Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exercise intolerance remains one of the major factors determining quality of life in heart failure patients. In 6 patients with heart failure with preserved ejection fraction (HFpEF) undergoing invasive cardiopulmonary exercise testing, balloon inflation within the inferior vena cava (IVC) was performed during exercise to reduce and maintain pulmonary arterial (PA) pressures. Partial IVC occlusion significantly reduced PA pressures without reducing cardiac output. Partial IVC occlusion significantly reduced respiratory rate at matched levels of exercise. These findings highlight the importance of pulmonary pressures in the pathophysiology of HFpEF and suggest that therapies targeting hemodynamics may improve symptoms and exercise capacity in these patients.

Indexed as

cardiac outputCPET, cardiopulmonary exercise testingheart failurehemodynamicsHFpEF, heart failure with preserved ejection fractionIVC, inferior vena cavaIVC occlusionLV, left ventricle/ventricularPA, pulmonary arteryPCWP, pulmonary capillary wedge pressureVCO2, carbon dioxide consumptionVO2, oxygen consumption

Identifiers

PMID33778208
PMCPMC7987536
OpenAlexW3130878004

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.