Evidence map›Paper›PMID 33777920›Full record

ArticleFrontiers in bioengineering and biotechnology2021

Rational Design of Hyaluronic Acid-Based Copolymer-Mixed Micelle in Combination PD-L1 Immune Checkpoint Blockade for Enhanced Chemo-Immunotherapy of Melanoma.

Chaopei Zhou, Xiuxiu Dong, Chunxiang Song, Shuang Cui, Tiantian Chen, Daji Zhang, Xiuli Zhao, Chunrong Yang

Open access · goldAbstract read
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Chaopei ZhouCollege Pharmacy, Jiamusi University, Jiamusi, China.
Xiuxiu DongCollege Pharmacy, Jiamusi University, Jiamusi, China.
Chunxiang SongCollege Pharmacy, Jiamusi University, Jiamusi, China.
Shuang CuiCollege Pharmacy, Jiamusi University, Jiamusi, China.
Tiantian ChenCollege Pharmacy, Jiamusi University, Jiamusi, China.
Daji ZhangCollege Pharmacy, Jiamusi University, Jiamusi, China.
Xiuli ZhaoSchool of Pharmacy, Shenyang Pharmaceutical University, Shenyang, China.
Chunrong YangCollege Pharmacy, Jiamusi University, Jiamusi, China.
Jiamusi University · CNShenyang Pharmaceutical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The application of combinational therapy breaks the limitation of monotherapy and achieves better clinical benefit for tumor therapy. Herein, a hyaluronic acid/Pluronic F68-based copolymer-mixed micelle was constructed for targeted delivery of chemotherapeutical agent docetaxel (PHDM) in combination with programmed cell death ligand-1(PD-L1) antibody. When PHDM+anti-PDL1 was injected into the blood system, PHDM could accumulate into tumor sites and target tumor cells

Indexed as

chemo-immunotherapy combinationsdrug delivery systemhyaluronic acidmixed micelleprogrammed cell death ligand 1 (PD-L1)

Identifiers

PMID33777920
PMCPMC7987940
OpenAlexW3135474580

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.