ArticleFrontiers in bioengineering and biotechnology2021
Stress-Strain Index Map: A New Way to Represent Corneal Material Stiffness.
Article in Frontiers in bioengineering and biotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Regional Biomechanical and Topographic Changes after Transepithelial vs. Epithelium-off Continuous Accelerated Corneal Cross-linking in Keratoconus: Updated Stress-Strain Index as a Superior Biomarker.Ophthalmology science · 2026Article
- Transformative biomechanics and mechanobiology breakthroughs shaping the future of health and medicine.Innovation (Cambridge (Mass.)) · 2026Review
- Staging of Keratoconus Indices Based on Localized Corneal Biomechanics Stress-Strain Index Map.Ophthalmology science · 2026Article
- Correlation Analysis of Bowman's Layer Microdistortions and Corneal Biomechanics Changes Evaluated by Brillouin Microscopy After KLEx.Clinical ophthalmology (Auckland, N.Z.) · 2026Article
- Regional corneal biomechanics assessment as a function of age using Strain-Stress Index maps.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2025Review
- Evaluating corneal cross-linking using Stress-Strain Index maps: a finite element study.Journal of the Royal Society, Interface · 2025Article
- Early diagnosis of keratoconus using corneal biomechanics and OCT derived technologies.Eye and vision (London, England) · 2025Review
- Comparing the Performance of Stress-Strain Index Versions 1 and 2 in Normal and Keratoconus Patients.Translational vision science & technology · 2025Article
- Corneal viscoelasticity is associated with intraocular pressure under physiological baseline: insights from the rheological properties of corneal lenticules.Frontiers in bioengineering and biotechnology · 2025Article
- Development and validation of the VAE-NT index: a novel biomechanical parameter for distinguishing subclinical corneal abnormalities.Frontiers in bioengineering and biotechnology · 2025Article
- [Anisotropy and viscoelasticity of different corneal regions in rabbit corneal ectasia model].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2024Article
- Corneal Biomechanical Measures for Glaucoma: A Clinical Approach.Bioengineering (Basel, Switzerland) · 2023Review
- Keratoconus Diagnosis: From Fundamentals to Artificial Intelligence: A Systematic Narrative Review.Diagnostics (Basel, Switzerland) · 2023Review
- Review
- Corneal Biomechanical Characteristics in Osteogenesis Imperfecta With Collagen Defect.Translational vision science & technology · 2023Article
- Change in the corneal material mechanical property for small incision lenticule extraction surgery.Frontiers in bioengineering and biotechnology · 2023Article
- Biomechanical analysis of ocular diseases and its in vitro study methods.Biomedical engineering online · 2022Review
- Long-Term Clinical Outcomes of Small-Incision Femtosecond Laser-Assisted Intracorneal Concave Lenticule Implantation in Patients with Keratoconus.Journal of ophthalmology · 2022Article
- Effect of myopia and astigmatism deepening on the corneal biomechanical parameter stress-strain index in individuals of Chinese ethnicity.Frontiers in bioengineering and biotechnology · 2022Article
- Article
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9 authors.
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Abstract
purposeTo introduce a new method to map the mechanical stiffness of healthy and keratoconic corneas.
methodsNumerical modeling based on the finite element method was used to carry out inverse analysis of simulated healthy and keratoconic corneas to determine the regional variation of mechanical stiffness across the corneal surface based on established trends in collagen fibril distribution. The Stress-Strain Index (SSI), developed and validated in an earlier study and presented as a parameter that can estimate the overall stress-strain behavior of corneal tissue, was adopted in this research as a measure of corneal stiffness. The regional variation of SSI across the corneal surface was estimated using inverse analysis while referring to the common features of collagen fibrils' distribution obtained from earlier x-ray scattering studies. Additionally, for keratoconic corneas, a method relating keratoconic cone features and cornea's refractive power to the reduction in collagen fibril density inside the cone was implemented in the development of SSI maps. In addition to the simulated cases, the study also included two keratoconus cases, for which SSI maps were developed.
resultsSSI values varied slightly across corneal surface in the simulated healthy eyes. In contrast, both simulated and clinical keratoconic corneas demonstrated substantial reductions in SSI values inside the cone. These SSI reductions depended on the extent of the disease and increased with more considerable simulated losses in fibril density in the cone area. SSI values and their regional variation showed little change with changes in IOP, corneal thickness, and curvature.
conclusionSSI maps provide an estimation of the regional variation of biomechanical stiffness across the corneal surface. The maps could be particularly useful in keratoconic corneas, demonstrating the dependence of corneal biomechanical behavior on the tissue's microstructure and offering a tool to fundamentally understand the mechanics of keratoconus progression in individual patients.
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