Evidence map›Paper›PMID 33777801›Full record

ArticleFrontiers in oncology2021

The Prolactin Inducible Protein Modulates Antitumor Immune Responses and Metastasis in a Mouse Model of Triple Negative Breast Cancer.

Chidalu A Edechi, Nnamdi M Ikeogu, Gloria N Akaluka, Lucas E L Terceiro, Mikayla Machado, Enitan S Salako, Aida F Barazandeh, Sam K P Kung, Jude E Uzonna, Yvonne Myal

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.9field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Chidalu A EdechiDepartment of Pathology, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB, Canada.
Nnamdi M IkeoguDepartment of Immunology, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB, Canada.
Gloria N AkalukaDepartment of Immunology, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB, Canada.
Lucas E L TerceiroDepartment of Pathology, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB, Canada.
Mikayla MachadoDepartment of Pathology, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB, Canada.
Enitan S SalakoDepartment of Immunology, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB, Canada.
Aida F BarazandehDepartment of Immunology, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB, Canada.
Sam K P KungDepartment of Immunology, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB, Canada.
Jude E UzonnaDepartment of Immunology, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB, Canada.
Yvonne MyalDepartment of Pathology, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB, Canada.
University of Manitoba · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The prolactin inducible protein (PIP) is expressed to varying degrees in more than 90% of breast cancers (BCs). Although high levels of PIP expression in BC has been shown to correlate with better prognosis and patient response to chemotherapy, some studies suggest that PIP may also play a role in metastasis. Here, we investigated the role of PIP in BC using the well-established 4T1 and E0771 mouse BC cell lines. Stable expression of PIP in both cell lines did not significantly alter their proliferation, migration, and response to anticancer drugs

Indexed as

breast cancerimmune responselung metastasismouse modelsprolactin inducible protein

Identifiers

PMID33777801
PMCPMC7994859
OpenAlexW3138570037

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.