ArticleFrontiers in oncology2021
Is the Depth of Invasion a Marker for Elective Neck Dissection in Early Oral Squamous Cell Carcinoma?
Article in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 54 citations in OpenAlex.
- [Neck dissection-more, less, targeted?]HNO · 2026Review
- Whole-slide mapping of tumor tissue fiber architecture via computational scattered light imaging.Biomedical optics express · 2026Article
- Lymph Node Metastasis in Head and Neck Squamous Cell Carcinoma: Evolving Prognostic Markers, Molecular Insights, and Implications for Precision Staging.Diagnostics (Basel, Switzerland) · 2026Review
- Review
- Assessment of occult cervical metastases in oral cavity squamous cell carcinoma: Findings from a tertiary-level hospital study.Journal of clinical and experimental dentistry · 2025Review
- Deep Invasion Volume of the Primary Nasopharyngeal Carcinoma Predicts Treatment Outcome.AJNR. American journal of neuroradiology · 2025Article
- Evaluating Depth of Invasion as a Continuous Prognostic Factor in Oral Squamous Cell Carcinoma.Head & neck · 2025Article
- Pathological Risk Factors for Occult Nodal Metastasis in Early-Stage Squamous Cell Carcinoma of the Oral Cavity.Indian journal of surgical oncology · 2024Article
- Predicting lymph node recurrence in cT1-2N0 tongue squamous cell carcinoma: collaboration between artificial intelligence and pathologists.The journal of pathology. Clinical research · 2024Article
- Prognostic Analysis Combining Histopathological Features and Clinical Information to Predict Colorectal Cancer Survival from Whole-Slide Images.Digestive diseases and sciences · 2024Article
- The Depth of Invasion and Level IV Cervical Node Metastasis in Patients with Clinically N0 Tongue Cancer.Head and neck pathology · 2024Article
- Depth of Invasion, Lymphovascular Invasion, and Perineural Invasion as Predictors of Neck Node Metastasis in Early Oral Cavity Cancers.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2023Article
- A preoperative nomogram model for the prediction of lymph node metastasis in buccal mucosa cancer.Cancer medicine · 2023Article
- WPOI-5: Accurately Identified at Intraoperative Consultation and Predictive of Occult Cervical Metastases.Head and neck pathology · 2023Article
- Human papillomavirus in oral squamous cell carcinoma using p16 and its co-relationship with cervical lymph node metastasis and clinicopathological parameters.Dental research journal · 2023Article
- High-Frequency Intraoral Ultrasound for Preoperative Assessment of Depth of Invasion for Early Tongue Squamous Cell Carcinoma: Radiological-Pathological Correlations.International journal of environmental research and public health · 2022Article
- The Potential of MET Immunoreactivity for Prediction of Lymph Node Metastasis in Early Oral Tongue Squamous Cell Carcinoma.Frontiers in oncology · 2021Article
- Statical Association between Clinical and Histopathological Parameters for Keratinocyte Carcinomas.Current health sciences journalArticle
- Accuracy of magnetic resonance imaging in the assessment of depth of invasion in tongue carcinoma: A systematic review and meta-analysis.National journal of maxillofacial surgeryReview
Corrections and comments
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Authors and funding
20 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe depth of invasion (DOI) is considered an independent risk factor for occult lymph node metastasis in oral cavity squamous cell carcinoma (OCSCC). It is used to decide whether an elective neck dissection (END) is indicated in the case of a clinically negative neck for early stage carcinoma (pT1/pT2). However, there is no consensus on the cut-off value of the DOI for performing an END. The aim of this study was to determine a cut-off value for clinical decision making on END, by assessing the association of the DOI and the risk of occult lymph node metastasis in early OCSCC.
methodsA retrospective cohort study was conducted at the Erasmus MC, University Medical Centre Rotterdam, The Netherlands. Patients surgically treated for pT1/pT2 OCSCC between 2006 and 2012 were included. For all cases, the DOI was measured according to the 8
resultsA total of 222 patients were included, 117 pT1 and 105 pT2. Occult lymph node metastasis was found in 39 of the 166 patients who received END. Univariate logistic regression analysis showed DOI to be a significant predictor for occult lymph node metastasis (odds ratio (OR) = 1.3 per mm DOI; 95% CI: 1.1-1.5,
conclusionThe DOI is a significant predictor for occult lymph node metastasis in early stage oral carcinoma. A NPV of 81% was found at a DOI cut-off value of 4 mm. Therefore, an END should be performed if the DOI is >4 mm.
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