Evidence map›Paper›PMID 33777685›Full record

ArticleActa pharmaceutica Sinica. B2021

An injectable micelle-hydrogel hybrid for localized and prolonged drug delivery in the management of renal fibrosis.

Xianyan Qin, Yingying Xu, Xu Zhou, Tao Gong, Zhi-Rong Zhang, Yao Fu

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta pharmaceutica Sinica. B, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 51 citations in OpenAlex.

  1. Trial
  2. Review
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  4. Article
  5. Advances in the Targeted Drug Delivery System for Renal Fibrosis.International journal of nanomedicine · 2026
    Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. Targeting renal tubular epithelial cellsActa pharmaceutica Sinica. B · 2025
    Article
  13. Smart hydrogels for in situ tissue drug delivery.Journal of biomedical science · 2025
    Review
  14. Article
  15. Review
  16. Article
  17. Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Xianyan QinKey Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
Yingying XuKey Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
Xu ZhouKey Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
Tao GongKey Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
Zhi-Rong ZhangKey Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
Yao FuKey Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
Sichuan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Localized delivery, comparing to systemic drug administration, offers a unique alternative to enhance efficacy, lower dosage, and minimize systemic tissue toxicity by releasing therapeutics locally and specifically to the site of interests. Herein, a localized drug delivery platform ("plum‒pudding" structure) with controlled release and long-acting features is developed through an injectable hydrogel ("pudding") crosslinked

Indexed as

Anti-TGFβ antibodybis-F127-MA, bis-F127-methacrylateBSA, bovine serum albuminCelastrolCLT, celastrolControlled releaseCy5.5-NHS, cyanine 5.5-N-hydroxysuccinimideDAPI, 4′,6-diamidino-2-phenylindoleDEX, dexamethasoneDiD, 1,1′-dioctadecyl-3,3,3′,3′-tetramethylindodicarbocyanineperchlorateECM, extracellular matrixEDCI, carbodiimide hydrochlorideESR, equilibrium swelling ratioFITC, fluorescein isothiocyanateG', storage modulusG", the loss modulusHA, hyaluronic acidHASH, thiolated hyaluronic acidHydrogelIL-1β, interleukin 1βIL-6, interleukin 6InflammationiNOS, nitric oxide synthaseLocalized therapyMOD, mean optical densityNHS, N-hydroxysuccinimidePDI, polydispersity index“Plum‒pudding” structureRenal fibrosisRIF, renal interstitial fibrosisRSR, real-time swelling ratioSD, standard deviationSEM, scanning electron microscopyTEM, transmission electron microscopyTGF-β1, transforming growth factor β1TNF-α, tumor necrosis factor αTUNEL, terminal deoxynucleotidyl transferase dUTP nick end labellingUUO, unilateral ureteral obstructionα-SMA, α-smooth muscle actin

Identifiers

PMID33777685
PMCPMC7982499
OpenAlexW3093332769

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.