Evidence map›Paper›PMID 33777671›Full record

ReviewActa pharmaceutica Sinica. B2021

Hedgehog signaling in gastrointestinal carcinogenesis and the gastrointestinal tumor microenvironment.

Jinghui Zhang, Jiajun Fan, Xian Zeng, Mingming Nie, Jingyun Luan, Yichen Wang, Dianwen Ju, Kai Yin

Open access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Acta pharmaceutica Sinica. B, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 88 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Jinghui ZhangDepartment of Gastrointestinal Surgery, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
Jiajun FanDepartment of Biological Medicines, Fudan University School of Pharmacy, Shanghai 201203, China.
Xian ZengDepartment of Biological Medicines, Fudan University School of Pharmacy, Shanghai 201203, China.
Mingming NieDepartment of Gastrointestinal Surgery, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
Jingyun LuanDepartment of Biological Medicines, Fudan University School of Pharmacy, Shanghai 201203, China.
Yichen WangDepartment of Biological Medicines, Fudan University School of Pharmacy, Shanghai 201203, China.
Dianwen JuDepartment of Biological Medicines, Fudan University School of Pharmacy, Shanghai 201203, China.
Kai YinDepartment of Gastrointestinal Surgery, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
Fudan University · CNChanghai Hospital · CNSecond Military Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Hedgehog (HH) signaling pathway plays important roles in gastrointestinal carcinogenesis and the gastrointestinal tumor microenvironment (TME). Aberrant HH signaling activation may accelerate the growth of gastrointestinal tumors and lead to tumor immune tolerance and drug resistance. The interaction between HH signaling and the TME is intimately involved in these processes, for example, tumor growth, tumor immune tolerance, inflammation, and drug resistance. Evidence indicates that inflammatory factors in the TME, such as interleukin 6 (IL-6) and interferon-

Indexed as

5-Fu, 5-fluorouracilALK5, TGF-β receptor I kinaseand leucovorin, GLIATO, arsenic trioxideBCC, basal cell carcinomaBCL-2, B cell lymphoma 2BMI-1, B cell-specific moloney murine leukemia virus insertion region-1CAFs, cancer-associated fibroblastsCancer stem cellsCarcinogenesisch5E1, chimeric monoclonal antibody 5E1CSCs, cancer stem cellsDHH, Desert HedgehogDrug resistanceEGF, epidermal growth factorFOLFOX, oxaliplatinGastrointestinal cancerglioma-associated oncogene homologue, GRK2G protein coupled receptor kinase 2, HHHedgehogHedgehog, HIF-1αhypoxia-inducible factor 1α, IFN-γ: interferon-γIHH, Indian HedgehogIL-10/6, interleukin 10/6ITCH, itchy E3 ubiquitin ligaseMDSCs, myeloid-derived suppressor cellsNK, natural killerNOX4, NADPH Oxidase 4PD-1, programmed cell death-1PD-L1, programmed cell death ligand-1PKA, protein kinase APTCH, PatchedROS, reactive oxygen speciesSHH, Sonic HedgehogSMAD3, mothers against decapentaplegic homolog 3SMO, SmoothenedSNF5, sucrose non-fermenting 5STAT3, signal transducer and activator of transcription 3SUFU, Suppressor of FusedTAMs, tumor-related macrophagesTGF-β, transforming growth factor βTME, tumor microenvironmentTumor microenvironmentVEGF, vascular endothelial growth factorWNT, Wingless/IntegratedβArr2, β-arrestin2

Identifiers

PMID33777671
PMCPMC7982428
OpenAlexW3097655109

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.