Evidence map›Paper›PMID 33777670›Full record

ReviewActa pharmaceutica Sinica. B2021

Targeting redox-altered plasticity to reactivate synaptic function: A novel therapeutic strategy for cognitive disorder.

Pei Wang, Fang Wang, Lan Ni, Pengfei Wu, Jianguo Chen

Open access · diamondAbstract readReview
In one paragraph

Review in Acta pharmaceutica Sinica. B, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 33 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Hydrogen Sulfide (HInternational journal of molecular sciences · 2025
    Review
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Pei WangDepartment of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Fang WangDepartment of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Lan NiDepartment of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Pengfei WuDepartment of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Jianguo ChenDepartment of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Huazhong University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Redox-altered plasticity refers to redox-dependent reversible changes in synaptic plasticity

Indexed as

AAMI, age-associated memory impairmentAD, Alzheimer's diseaseAMPARs, α-amino-3-hydroxyl-5-methyl-4-isoxazolepropionate receptorsCaMKII, Ca2+/calmodulin-dependent protein kinase IICognitive disorderDG, dentate gyrusDS, Down syndromeDTNB, 5,5-dithio-bis-2-nitrobenzoic acidDTT, dithiothreitolEPSPs, excitatory postsynaptic potentialsGlu, glutamateGSK-3β, glycogen synthase kinase-3βH2O2, hydrogen peroxideHFS, high-frequency stimulationHydrogen sulfideLearning and memoryLFS, low-frequency stimulationLong-term potentiationLTD, long-term depressionLTP, long-term potentiationMF, mossy fiberNAC, N-acetyl cysteineNADPH, nicotinamide adenine dinucleotide phosphateNMDARs, N-methyl-d-aspartate receptorsN-Methyl-d-aspartate receptorNO, nitric oxideOxidative stressPTM, posttranslational modificationReactive oxygen speciesROS, reactive oxygen speciesSC, Schaffer collateralSNOC, S-nitrosocysteineSynaptic plasticityTFAM, mitochondrial transcription factor AVD, vascular dementia

Identifiers

PMID33777670
PMCPMC7982492
OpenAlexW3107516906

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.