Evidence map›Paper›PMID 33777658›Full record

ArticleCurrent stem cell reports2020

Stem Cell Metabolism and Diet.

Marine Barthez, Zehan Song, Chih Ling Wang, Danica Chen

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current stem cell reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Marine BarthezProgram in Metabolic Biology, Nutritional Sciences & Toxicology, University of California, Berkeley, CA 94720.
Zehan SongProgram in Metabolic Biology, Nutritional Sciences & Toxicology, University of California, Berkeley, CA 94720.
Chih Ling WangProgram in Metabolic Biology, Nutritional Sciences & Toxicology, University of California, Berkeley, CA 94720.
Danica ChenProgram in Metabolic Biology, Nutritional Sciences & Toxicology, University of California, Berkeley, CA 94720, 119 Morgan Hall, University of California, Berkeley, CA 94720.
University of California, Berkeley · US

Funding

Inflammation and Aging-associated DiabetesR01AG063389 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI CHEN, DANICA · 2019 to 2023
$2.0M
Nutrient Sensing, Hematopoietic Stem Cell Metabolism and AgingR01AG063404 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI CHEN, DANICA · 2018 to 2022
$2.0M
Hematopoietic Stem Cell AgingR01DK117481 · NIDDK · UNIVERSITY OF CALIFORNIA BERKELEY · PI CHEN, DANICA · 2018 to 2021
$1.7M
Obesity and HematopoiesisR01DK101885 · NIDDK · UNIVERSITY OF CALIFORNIA BERKELEY · PI CHEN, DANICA · 2015 to 2017
$942k
NIA NIH HHS R01 AG063389NIA NIH HHS R01 AG063404NIDDK NIH HHS R01 DK101885NIDDK NIH HHS R01 DK117481
6 · The paper itself

Abstract

purpose of reviewDiet has profound impacts on health and longevity. Evidence is emerging to suggest that diet impinges upon the metabolic pathways in tissue-specific stem cells to influence health and disease. Here, we review the similarities and differences in the metabolism of stem cells from several tissues, and highlight the mitochondrial metabolic checkpoint in stem cell maintenance and aging. We discuss how diet engages the nutrient sensing metabolic pathways and impacts stem cell maintenance. Finally, we explore the therapeutic implications of dietary and metabolic regulation of stem cells. RECENT

findingsStem Cell transition from quiescence to proliferation is associated with a metabolic switch from glycolysis to mitochondrial OXPHOS and the mitochondrial metabolic checkpoint is critically controlled by the nutrient sensors SIRT2, SIRT3, and SIRT7 in hematopoietic stem cells. Intestine stem cell homeostasis during aging and in response to diet is critically dependent on fatty acid metabolism and ketone bodies and is influenced by the niche mediated by the nutrient sensor mTOR. SUMMARY: Nutrient sensing metabolic pathways critically regulate stem cell maintenance during aging and in response to diet. Elucidating the molecular mechanisms underlying dietary and metabolic regulation of stem cells provides novel insights for stem cell biology and may be targeted therapeutically to reverse stem cell aging and tissue degeneration.

Indexed as

calorie restrictionmTORSIRT2SIRT3SIRT7stem cell metabolism

Identifiers

PMID33777658
PMCPMC7992378
OpenAlexW3096288874

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.