Evidence map›Paper›PMID 33777657›Full record

ArticleCurrent molecular biology reports2020

Senolytics: targeting senescent cells for age-associated diseases.

Iman M A Al-Naggar, George A Kuchel, Ming Xu

Abstract read
In one paragraph

Article in Current molecular biology reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Molecular mechanisms of aging and anti-aging strategies.Cell communication and signaling : CCS · 2024
    Review
  11. Transplanting old organs promotes senescence in young recipients.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2024
    Article
  12. Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Iman M A Al-NaggarUConn Center on Aging, UConn Health, Farmington, Connecticut, USA.
George A KuchelUConn Center on Aging, UConn Health, Farmington, Connecticut, USA.
Ming XuUConn Center on Aging, UConn Health, Farmington, Connecticut, USA.

Funding

Targeting p21-positive Senescent Cells in vivo for Alleviating Metabolic and Physical DysfunctionR01AG066679 · NIA · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI XU, MING · 2020 to 2024
$2.2M
Role of Senolytics in Lower Urinary Tract Aging and Voiding DisordersR21AG063528 · NIA · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI KUCHEL, GEORGE A, SMITH, PHILLIP PAUL · 2019 to 2020
$440k
NIA NIH HHS R01 AG066679NIA NIH HHS R21 AG063528
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AgingCellular senescenceHealthspanLifespanSenolytics

Identifiers

PMID33777657
PMCPMC7992369

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.