Evidence map›Paper›PMID 33777645›Full record

ArticleCurrent addiction reports2020

Treatment Implications Associated with Cannabis and Tobacco Co-Use.

Erin A McClure, Rachel A Rabin, Dustin C Lee, Chandni Hindocha

Open access · greenAbstract read
In one paragraph

Article in Current addiction reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.

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  8. Past-Month Tobacco and Cannabis Co-Use by Chronic Disease and Sociodemographic Factors Among U.S. Adults 65+ Years (2021-2023).Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2026
    Article
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  10. Effect of Comorbidities on Short-Term Postoperative Complications Following total Shoulder Arthroplasty: A TriNetX Study.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 4 countries.

Erin A McClureDepartment of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA.ORCID 0000-0001-9744-7818
Rachel A RabinDepartment of Psychiatry, McGill University and The Douglas Mental Health Institute, Montreal, Canada.ORCID 0000-0002-6530-0288
Dustin C LeeDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-4818-9733
Chandni HindochaClinical Psychopharmacology Unit, Department of Clinical, Educational & Health Psychology, University College London, Faculty of Brain Sciences, University College London.ORCID 0000-0003-1692-7401
Douglas Mental Health University Institute · CAJohns Hopkins Medicine · USMedical University of South Carolina · USUniversity College London · GB

Funding

South Carolina Clinical & Translational Research Institute (SCTR)UL1TR001450 · NCATS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BRADY, KATHLEEN T., FLUME, PATRICK A · 2015 to 2024
$41.1M
Determining the impact of cannabis use and severity on tobacco cessation outcomes: A prospective tobacco treatment trialR37CA237245 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI MCCLURE, ERIN A · 2019 to 2025
$4.2M
NCATS NIH HHS UL1 TR001450NCI NIH HHS R37 CA237245
6 · The paper itself

Abstract

purpose of the reviewThe goal of this article is to summarize the treatment-focused literature on cannabis and tobacco co-use and the treatment implications of co-use. This review will focus on: 1) the impact of co-use on cessation outcomes, 2) compensatory use/substitution of the non-treated substance among co-users, and 3) treatment interventions to address co-use. This article will highlight the limitations to co-use captured in the literature and offer considerations and directives for co-use research and treatment moving forward. RECENT

findingsThe degree to which co-use affects cessation for a single, targeted substance remains in question, as the literature is largely mixed. Cannabis treatment trials are better equipped to answer these questions given that they do not typically exclude tobacco users. While the relationship between tobacco use and poorer cannabis outcomes appears to have some evidence, the reverse relationship (cannabis use affecting tobacco outcomes) is not consistently supported. SUMMARY: The co-use of cannabis and tobacco and its impact on single substance cessation and/or compensatory substance use during cessation is generally overlooked in treatment trials, while interventions to address both substances are rare. Capturing co-use adds burden for researchers, clinicians, and participants, but is warranted given the prevalence of co-use and a rapidly changing cannabis and tobacco regulatory environment, which may further complicate co-occurring substance use. Co-users are a heterogeneous population; trials focused on co-users, in addition to better data capture and consistent terminology, will aid in an understanding of nuanced patterns of co-use critical to inform treatment interventions.

Indexed as

cannabiscessationco-usepolysubstance usesubstitutiontobaccotreatment

Identifiers

PMID33777645
PMCPMC7992053
OpenAlexW3089343962

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.