Evidence map›Paper›PMID 33777320›Full record

ArticleOxidative medicine and cellular longevity2021

Zi Shen Decoction Inhibits Growth and Metastasis of Lung Cancer via Regulating the AKT/GSK-3

Yanxia Ma, Yu Liu, Linxin Teng, En Luo, Dekang Liu, Fuqiong Zhou, Kaiyuan Wang, Weiping Chen, Lei Bi

Abstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Promising Advances in LINC01116 Related to Cancer.Frontiers in cell and developmental biology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yanxia MaSchool of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China.ORCID https://orcid.org/0000-0002-6002-3912
Yu LiuSchool of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China.ORCID https://orcid.org/0000-0002-8558-7300
Linxin TengSchool of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China.ORCID https://orcid.org/0000-0002-2948-3179
En LuoSchool of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China.ORCID https://orcid.org/0000-0001-7768-3186
Dekang LiuSchool of Medicine and Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Fuqiong ZhouSchool of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China.ORCID https://orcid.org/0000-0003-1115-661X
Kaiyuan WangSchool of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China.ORCID https://orcid.org/0000-0002-6949-8500
Weiping ChenSchool of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Lei BiSchool of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China.ORCID https://orcid.org/0000-0002-2951-0966

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lung cancer has become the leading cause of cancer-related death worldwide. Oxidative stress plays important roles in the pathogenesis of lung cancer. Many natural products show antioxidative activities in cancer treatment. Zi Shen decoction (ZSD) is a classic prescription for the treatment of lung disease. However, its effect on lung cancer lacks evidence-based efficacy. In this study, we investigated the anticancer effects of ZSD on lung cancer

Indexed as

Carcinoma, Lewis LungLung NeoplasmsAnimalsbeta CateninDrugs, Chinese HerbalGlycogen Synthase Kinase 3 betaMaleMiceNeoplasm MetastasisProto-Oncogene Proteins c-aktSignal Transductionbeta CateninCTNNB1 protein, mouseDrugs, Chinese HerbalGlycogen Synthase Kinase 3 betaGsk3b protein, mouseProto-Oncogene Proteins c-akt

Identifiers

PMID33777320
PMCPMC7969097

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.