Evidence map›Paper›PMID 33777189›Full record

ArticleExperimental and therapeutic medicine2021

miR-23a-3p regulates the proliferation and apoptosis of human lens epithelial cells by targeting Bcl-2 in an

Pengxiang Yao, Jian Jiang, Xiaoping Ma, Zhenzhong Chen, Yufang Hong, Yang Wu

Open access · diamondAbstract read
In one paragraph

Article in Experimental and therapeutic medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Pengxiang YaoDepartment of Ophthalmology, Zhongshan Hospital Xiamen Branch, Fudan University, Xiamen, Fujian 361000, P.R. China.
Jian JiangDepartment of Ophthalmology, Xiangya Hospital, Central South University, Changsha, Hunan 410000, P.R. China.
Xiaoping MaDepartment of Ophthalmology, Zhongshan Hospital Xiamen Branch, Fudan University, Xiamen, Fujian 361000, P.R. China.
Zhenzhong ChenDepartment of Ophthalmology, Zhongshan Hospital Xiamen Branch, Fudan University, Xiamen, Fujian 361000, P.R. China.
Yufang HongDepartment of Ophthalmology, Zhongshan Hospital Xiamen Branch, Fudan University, Xiamen, Fujian 361000, P.R. China.
Yang WuDepartment of Ophthalmology, Zhongshan Hospital Xiamen Branch, Fudan University, Xiamen, Fujian 361000, P.R. China.
Fudan University · CNZhongshan Hospital of Xiamen University · CNCentral South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cataracts account for ~50% of the cases of blindness in individuals worldwide. The apoptosis of lens epithelial cells (LECs) occurs during the formation of cataracts, which is a non-congenital condition. Numerous microRNAs (miRs) have been reported to regulate apoptosis in LECs. For instance, miR-23a expression levels were shown to be upregulated in cataractous lenses; however, the function of miR-23a in cataracts remains undetermined. To establish an

Indexed as

apoptosisBcl-2cataractslens epithelial cellsmicroRNA-23a-3pproliferation

Identifiers

PMID33777189
PMCPMC7967796
OpenAlexW3135297964

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.